Executive Medical Director, Global Medical Lead (Pain)

• Leadthedevelopmentimplementationexecution and communication of theIntegrated Medical Plansincludingbut not limited tomedical strategyglobal tactical planpublicationcongressandpost-approval evidence generationplanin collaboration with Clinical Development HEOR RWE Medical Writing and other internal stakeholders across Vertex

• Ensure alignment of medical strategy with organizationalobjectivesby integrating individualand disease area team goalswith Vertex and DST prioritiesand the goals of cross-functional partners

• Expertlydistillsinsightsand actionable outcomesthatinformstrategy anddrive the greatest impact for Medical Affairs

• Establishes and tracks medical KPIs thatdemonstrateimpact on business and patient outcomes.

• Applies structured problem-solving and root cause analysis toidentifysolutionsand make decisionsthat maximize medical and business impact

• Able toidentifywhat is important and impactful to medical and the wider businessprioritize competing demandsand communication to key stakeholders

• Accountablefor development of theglobalDA budget management of funds allocation and associated tracking to ensure alignment with Medical Affairs priorities andefficient resource allocation

Scientific Excellence

• Serve as product and disease area expert and primary contact point for all globaldisease area related issues with the external community and internally at Vertex

• Able toleaddevelopment of peer reviewed publications congresspresentationsand evidence generation to shape clinical practice

• Closely follow medical developments within disease area anddisseminatenew informationto transform clinical trends and emerging data into new plans

• Lead the development of global scientific communications and materials including materials for globalledsymposia advisory boards and training.

• Accountable for medical review of assigned brand related contentand global medical content aligned with Vertex SOPs

External Partnerships

• Represent Vertex at scientific and medical forums including medical education forums scientific societies patient advocacy groups and congresses.

• Accountable for engaging and cultivating relationships with leading global key thought leaders (TL) to gain greater understanding of thediseasearea and insights into unmet patient needs

Medical Communication

• Tailorscommunicationto stakeholder needs building trust and understanding across diverse audiences.

• Deliver external presentations (advisory board meetings symposia other medical education meetings) to enhance the medical knowledge of pipeline and marketed products asandin accordance withrelevant regulations and procedures

• Support disease area training across the company as

• Responsible for medical interpretation of data (clinical trials registries published literature etc.) forpipeline therapies andmarketed medicines

RegionalMedicaland Cross FunctionalCollaboration

• Accountable for go to market model and medical partnership in commercializationwith global cross-functional absenceofregionsteamscountrygo to market modelremainsthe responsibility ofthe GML.

• Support regional Medical Affairs and Medical Excellence teams fromlaunchthrough lifecycle viatimelydelivery of fit-for-purpose training and core materials.

• Responsible for driving alignment on medical content/messaging within the organization to ensure maximalfunctionaland regional input.

• Medical Affairsleaderon key global cross-functional product and development strategic focused teamsincluding DST and relevantsub teams

• Effectivelyrepresentsand communicates DST priorities to the medical function and proactively communicates andrepresentsmedical needs to DST

• Chair the Global Medical Area Team (GMAT) for the diseaseareaand accountable for deliverables

• Provide strategicMedical Affairsleadershipon relevant commercial teams: Launch Team and Global brand teams for product

• RepresentMedical Affairs in label discussions

• Support Access Patient Advocacy Policy and Corporate Communications teams with medical/scientificexpertiseand materials review.

Evidence Generation and Access

• Leads strategydevelopmentand execution ofLife Cycle Managementin partnership with HEOR includingIntegratedEvidence Generation plan in close collaboration withkey internal stakeholders

• May act as medical monitor for studies falling under the Medical Affairs scope in collaboration with Clinical Development Real World Evidence Health Economics and Outcomes Research and Clinical Operations

• Lead oversight and management of ISS programs and in collaboration with Regional Medical leadership conduct critical scientific and medical review of ISS protocols

• As applicable lead Managed Access Committee for assets with a Managed Access Program (MAP); may act as a Medical Monitor for MAP

Team/People Management

• Provide strong leadership todedicateddisease areamedicalteam inspiringand empoweringa dedicated medical teamand promoting a culture of continuous development.

• Accountable for therecruitment development management and coaching theglobalmedical team

• Leverages the capabilities andexpertiseof the team to ensure successful execution of medical plans

• Identifiesand addresses team skill gaps considering how to accelerate internal talent or attract external to meetneedsof a future-ready organization.

• Adheres toformalgoal-settingtalent and performance cycles ensuringindividual development plans (IDPs)are in place

• Navigates ambiguous or rapidly evolving situations andcoachthe team during periods of uncertainty or change.

Compliance and Pharmacovigilance:

• Ensure complianceofmedical activities according to global and regionalguidelines andin accordance withVertexCode of Conduct rules and regulations company policies SOPs GCP and ICH

• Ensure self and othermedicalcolleagueshave the required skills toidentifyand report AEsappropriately

• Contribute to managing external communication when significant safety issues arise with the wellbeing of patients being theultimate goal