Senior Computational Biologist, Immunology

Your work will change lives. Including your own.

The Impact Youll Make

As a key member of Recursions partnership-facing data science team you will be at the forefront of reimagining drug discovery from first principles using Recursions massive data and compute capabilities. As senior computational biologist you will be supporting partnership portfolio of preclinical drug programs and be responsible for designing and executing analyses to support target nomination validation and early programs in immunology and inflammation (I&I) diseases translationally validates disease contexts in hit-to-lead and accelerates in vivo work in lead optimization.

You will integrate layers of Recursion platform data (phenomics transcriptomics proteomics etc) to validate the link between target and disease biology and to propose targets and early programs in novel areas of immunology and inflammation. You will partner with biologists and medicinal chemists to build supporting data packets for targets from our phenomic maps target screens and partnered patient data sets. You will also collaborate with computational scientists from across the organization to develop deploy and scale novel approaches to: 1) translational validation in hit to lead 2) mechanism-of-action identification/de-risking and 3) build evidence for patient connectivity to match the medicines we are creating to the patients who need them.

In this role you will:

• Deliver biological insights on therapeutic candidates and disease biology from the analysis of high-dimensional (phenomics transcriptomics proteomics patient-derived) datasets that support clinical development planning
• Evaluate the molecular evidence for therapeutic hypotheses and accelerate drug program progression into the clinic
• Present data analysis to decision makers and stakeholders in a clear and compelling way that drives toward getting medicines to patients
• Assess new data sources develop and scale new analysis methods and support key program decisions with the ultimate goal of bringing life-changing therapies to patients at unprecedented speed
• Industrialize analysis approaches to not only solve for the current project but also to accelerate future projects and scale the impact that we can have
• Collaborate cross-functionally with Recursions data science biology medicinal chemistry and platform teams to further advance Recursions ability to interpret and translate large-scale data assets into therapeutic programs

The Team Youll Join

Our group is a bold agile diverse collective of computational drug discovery scientists deeply focused on the singular goal of bringing new therapeutics into the clinic at an accelerated pace. We are a computational group that spans precision oncology I&I (immunology and inflammation) and neuroscience and focuses on advancing novel targeted therapies for these disease areas. We partner closely with our biologists and medicinal chemists to design and execute impactful and decisional data analysis for multiple programs. We are responsible for data strategy across the portfolio and supported by computational leadership in designing scalable and reproducible experiments that serve to advance multiple programs within the portfolio.

Our team collaborates extensively with computational biologists in other therapeutic areas (neurobiology oncology etc.) as well as data scientists and engineers from our core platform teams to provide a strong network of feedback and support.

The Experience Youll Need

• PhD in a relevant field (computational biology systems biology bioinformatics immunology/inflammation biology immuno-oncology etc.) with a very strong computational focus and 3 years of experience in biotech or pharma industry OR MS in a relevant field and 5 years of experience in biotech or pharma industry solving fundamental problems in immunology or drug discovery
• Experience with one or more immunology or inflammation disease areas;
• Experience applying computational methods (including probabilistic statistical and/or machine learning techniques) to analyze and integrate matched human clinical and molecular data in a high-level programming language such as Python or R
• Deep expertise in the analysis and data integration of one or more omics data modalities (phenomics transcriptomics proteomics genomics)Exceptional data visualization skills
• Excellent cross-functional communication skills including an ability to explain complex scientific concepts to a variety of audiences using a combination of plots documents and presentations

Nice To Have:

• Strong understanding of patient genetics and historical druggability of disease-relevant pathways including experience working with patient data
• Experience in efficiently advancing drug programs from proof of concept and into clinical development
• Experience with immunology and inflammation clinical trial biomarker analysis

Working Location & Compensation:

This is an office-based hybrid position at our UK headquarters located in London England. Employees are expected to work in the office at least 50% of the time.

At Recursion we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role the estimated current annual base range for this role is 86300 - 115500 (GBP). You will also be eligible for an annual bonus and equity compensation as well as a comprehensive benefits package.

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The Values We Hope You Share:

• We act boldly with integrity. We are unconstrained in our thinking take calculated risks and push boundaries but never at the expense of ethics science or trust.
• We care deeply and engage directly. Caring means holding a deep sense of responsibility and respect - showing up speaking honestly and taking action.
• We learn actively and adapt rapidly. Progress comes from doing. We experiment test and refine embracing iteration over perfection.
• We move with urgency because patients are waiting. Speed isnt about rushing but about moving the needle every day.
• We take ownership and accountability. Through ownership and accountability we enable trust and autonomyleaders take accountability for decisive action and teams own outcomes together.
• We are One Recursion. True cross-functional collaboration is about trust clarity humility and impact. Through sharing we can be greater than the sum of our individual capabilities.

Our values underpin the employee experience at Recursion. They are the character and personality of the company demonstrated through how we communicate support one another spend our time make decisions and celebrate collectively.

More About Recursion

Recursion (NASDAQ: RXRX) is a clinical stage TechBio company leading the space by decoding biology to radically improve lives. Enabling its mission is the Recursion OS a platform built across diverse technologies that continuously generate one of the worlds largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine-learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale up to millions of wet lab experiments weekly and massive computational scale owning and operating one of the most powerful supercomputers in the world Recursion is uniting technology biology and chemistry to advance the future of medicine.

Recursion is headquartered in Salt Lake City where it is a founding member of BioHive the Utah life sciences industry collective. Recursion also has offices in Toronto Montréal New York London Oxford area and the San Francisco Bay area. Learn more at or connect onX (formerly Twitter)andLinkedIn.

Recursion is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity national origin age disability veteran status or any other characteristic protected under applicable federal state local or provincial human rights legislation.

Accommodations are available on request for candidates taking part in all aspects of the selection process.

Recruitment & Staffing Agencies: Recursion Pharmaceuticals and its affiliate companies do not accept resumes from any source other than candidates. The submission of resumes by recruitment or staffing agencies to Recursion or its employees is strictly prohibited unless contacted directly by Recursions internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Recursion and Recursion will not owe any referral or other fees. Our team will communicate directly with candidates who are not represented by an agent or intermediary unless otherwise agreed to prior to interviewing for the job.