Principal Associate
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Monthly Salary:
Posted on:
5 hours ago
Vacancies:
1 Vacancy
Job Summary
At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.
The Position
At Roche over 90000 colleagues are working together and doing what patients need next. Our ambition is to deliver novel therapeutics diagnostic solutions and insights to patients with game changing clinical benefits. Antibody Engineering at Roche Innovation Center Shanghai is seeking a talented and experienced Senior Associate or Principal Associate for antibody discovery work including antibody hits identification by phage or yeast display systems library build and the characterization and optimization of lead antibody compounds. The final position offered depends the experience level of the candidate. Actual responsibilities will vary according to specific roles. The position requires the candidate to execute phage/yeast display screening development and screening of in vitro binding assays and functional cell-based assays to contribute to optimization of therapeutic antibody leads. The successful candidate will work with dynamic and highly motivated teams to drive the development of antibody therapeutics for unmet medical needs. The candidate will collaborate effectively with colleagues in Antibody Engineering Lead Discovery Protein Sciences Structural Biology Immunology Oncology and Pharmaceutical Sciences.
RESPONSIBILITIES
Execute yeast and/or phage based display system for antibody discovery. Experience for library-build and single B cell workflow will be greatly valued but not a must.
Develop and perform in vitro binding assays for the screening and characterization of therapeutic antibody hits including immuno-binding assays including ELISAs FACS affinity measurement assays antibody epitope mapping assays and functional biochemical and cell-based assays in various disease areas
Execute profiling/screening to deliver data to guide lead optimization
Monitor outsourcing activities at CROs to ensure timely delivery of qualified data to steer portfolios
Independently analyzes interprets and presents results within and outside Antibody Engineering
Coordinates cross-functional efforts to meet near-term or long-term project goals
CANDIDATE PROFILE
Qualification and experience
The candidate qualifications include an MS degree in biochemistry cell biology or molecular biology and at least 5 years of recent relevant antibody discovery experience preferably in a biopharmaceutical industry setting.
Competencies
The ideal candidate will have demonstrated competence in the following areas:
Deep hands-on experience in molecular biology biochemical and cell-based assay development and familiar with relevant instruments
Hands-on experience in yeast/phage display technologies and related workflows in the context of antibody discovery
Familiar with high-throughput & high-content screening set up and relevant instruments.
Experience in Immunology Oncology and other disease areas is highly desirable
Experience with single B cell system is highly desirable
Proven ability in independent and reliable execution of antibody discovery work with a persistent record of productivity agile problem solving capability and aptitude in quickly learning new technologies/skills.
Excellent communication and collaboration skills with a deep commitment to working in a fast paced team setting.
Who we are
A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver life-changing healthcare solutions that make a global impact.
Lets build a healthier future together.
Roche is an Equal Opportunity Employer.
Required Experience:
Staff IC
Key Skills
- Business Development
- Classroom Experience
- Dayforce
- Go
- Cloud Computing
- AWS
- Teaching
- Administrative Experience
- Leadership Experience
- negotiation
- SAS
- Data Analysis Skills
About Company
F. Hoffmann-La Roche AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has bearer shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel.
