Associate Scientist IIScientist I (Biologics Expression and Purification)
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Job Location:
Rockville, MD - USA
Monthly Salary:
$ 67200 - 102500
Posted on:
23 hours ago
Vacancies:
1 Vacancy
Job Summary
MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies.â Our team of350 dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer.âOur products and platforms have attracted multiple partnerships with leading pharmaceuticaland biotechnologycompanies around the globe.
The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics corporate culture promotes an atmosphere of innovation open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.
Summary of Position
As a member of the Protein Science team this individual will set up transfections to express proteins in mammalian cells followed by their purification and characterization to support the Biologics discovery pipeline.
Job duties
- Culture of mammalian cells in suspension following aseptic techniques and cell-line specific protocols.
- Transient transfection of cell lines or expansion of stable cell pools from 3 ml 10 L scale to express proteins of interest. Monitor and optimize culture conditions to maximize protein quality and expression.
- Protein purification from milligram to gram scale using semi-automated FPLC systems.
- Analytical characterization of purified proteins to support research projects for drug discovery.
- Collect analyze and summarize experimental data in electronic lab notebook for archiving and sharing.
- Maintain lab and lab equipment in optimal functioning condition. Report any problems to supervisor.
Qualifications:
Education/Experience
Associate Scientist II
- Bachelors degree in Biology or Biochemistry or a related field of study with a minimum of 2 years of bench-related experience
Scientist I
- Bachelors degree in Biology or Biochemistry or a related field of study with a minimum of 3 years of bench-related experience
or
Masters degree in Biology or Biochemistry or a related field of study. Laboratory experience gained through undergraduate coursework graduate research or an internship is required. A minimum of 1 year of bench-related experience strongly preferred.
Knowledge Skills and Abilities
- Experience with mammalian cell culture transfections maintaining cell lines etc. with meticulous sterile technique and lab practices.
- Experience with recombinant protein purification and analytical characterization (CE or SDS-PAGE SEC).
- Experience with experimental design and execution with minimal supervision.
- Experience with standard lab software for data analysis (MS Excel Prism etc.). Good organizational skills and ability to multi-task.
- Good verbal and written communication skills. Demonstrated ability to work in a collaborative environment with other team members.
- Willingness to work on occasional weekends.
Preferred Experience
- Experience with antibody purification using automated FPLC system.
- Experience with quantitative assays (BLI Octet ELISA etc.).
Supervisory Responsibilities: None
Additional Information
The annual rate of pay for the Associate Scientist II position ranges from $67200 - $102500. The annual rate of pay for the Scientist I position ranges from $84400 - $128800. For non-exempt roles and according to applicable regulations there may be the possibility for overtime pay. This role is eligible for the Companys discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Companys benefits programs including medical / dental / vision / prescription coverage employee wellness resources 401(k) plan with employer match access to an Employee Stock Purchase Plan (ESPP) paid time off & paid parental leave benefits and disability benefits.
The annual pay rate range is described in good faith and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidates experience qualifications geographic location and other factors permitted by law. The Company may ultimately pay more or less than the posted range and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned vested and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus commission benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole discretion unless and until paid and may be modified at the Companys sole discretion consistent with the law.
Statement
MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race color national origin sex gender identity sexual orientation religion age disability protected veteran status or any other characteristic protected by federal state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the employment process please email or call and/or 711 for TTD/TTY service.
Equal Opportunity Employer/Veterans/Disabled
We do notaccept non-solicited resumes or candidate submittals from search/recruiting agencies.
Required Experience:
IC
Key Skills
- Laboratory Experience
- ELISA
- Immunoassays
- Transfection
- Mammalian Cell Culture
- Suspension Experience
- Biochemistry
- Assays
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
As a biopharmaceutical company, our team of dedicated individuals is focused on discovering and developing innovative antibody-based therapeutics designed to modulate the human immune response for the treatment of cancer. Our core scientific expertise is in the field of protein engine ... View more
