Senior Director, Global Regulatory Strategy Early Development & Business Development

Job Title: Senior Director Global Regulatory Strategy - Early Development & Business Development
Location: Boston MA

At AstraZeneca we pride ourselves on crafting a collaborative culture that champions knowledge-sharing ambitious thinking and innovation ultimately providing employees with the opportunity to work across teams functions and even the globe.

Recognizing the importance of individualized flexibility our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office is purposely designed with collaboration in mind providing space where teams can come together to strategize brainstorm and connect on key projects.

As AstraZeneca continues to put patients at the forefront of our mission we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release

At Alexion Rare Disease everything we do is underpinned by our dedication to being a Great Place to Work. Put simply our people are our greatest asset. We know that with a talented brave and diverse team that believes in making a meaningful impact for people living with rare diseases every day incredible things happen.

Joining Alexion means embracing an opportunity where work isnt ordinary in a company where Here it means more is more than a statement its an ethos. We are a beacon in the global BioPharmaceutical landscape. Our closeness to patients brings us closer to our work and closer to each other. Combined with our brave pioneering spirit we are truly unique in R&D and healthcare. At Alexion grow and innovate in a business with a rapidly expanding portfolio. Enjoy the vibe entrepreneurial spirit and autonomy of a leading biotech. Youll join an energising and kind culture where people build connections to explore new ideas and learn. As an important member of our commercial team youll be meeting the needs of some of the most underserved patients in the world.

Introduction to Role:

The Senior Director Global Regulatory Strategy will spearhead regulatory strategy for early-stage programs and lead regulatory due diligence for business development opportunities. You will integrate robust scientific expertise into regulatory decision-making ensuring clinical development plans are both scientifically sound and aligned with global health authority expectations. You will shape global regulatory pathway design for novel therapeutics ensure alignment with Alexions portfolio strategy and provide expert guidance to cross-functional teams. This role requires deep regulatory expertise strategic vision and the ability to influence internal and external stakeholders effectively.

Accountabilities:

• Provide expert regulatory guidance to preclinical and clinical teams shaping clinical development plans for candidate assets; represent regulatory at governance forums.
• Lead regulatory due diligence assessments for licensing acquisitions and partnerships opportunities; evaluate regulatory risks/opportunities and integrate new assets into Alexions portfolio.
• Serve as Global Regulatory Lead for assigned assets including new modalities (cell/gene therapy) or rare oncology programs.
• May act as the primary liaison with FDA EMA and other global agencies and lead critical interactions (pre-IND Scientific Advice).
• Partner with R&D Clinical Development and Commercial teams to align regulatory strategy with business objectives and portfolio priorities.
• Champion innovative regulatory approaches (e.g. expedited pathways novel trial designs real-world evidence) while ensuring the highest standards of GxP compliance.
• Build regulatory team capabilities in due diligence and business development by providing hands-on coaching and mentoring.

Essential Skills/Experience:

• Masters degree in a relevant scientific discipline (or equivalent knowledge/experience).
• 10 years of pharmaceutical industry experience in global regulatory strategy with strong scientific and clinical development expertise.
• Proven ability to evaluate and interpret nonclinical data to build robust IND-enabling packages and support efficient clinical development strategies across multiple therapeutic areas.
• Previous experience working on due diligence activities and business alliance environments including integrating new assets and driving portfolio growth.
• Experience providing strategic regulatory advice for the global development of products through all stages of development including pre-approval and marketed assets.
• Comprehensive knowledge of FDA EMA and ICH guidelines; experience with various therapeutic modalities (biologics small molecules cell/gene therapy).
• Demonstrated ability to innovate lead change and solve critical regulatory science questions in a dynamic environment.
• Exceptional written and verbal communication skills with influence across functions and geographies.
• Ability to build relationships and work collaboratively at all levels in a global matrixed organization.

Desirable Skills/Experience:

• Multi-regional experience (US EU Japan Emerging Markets)
• Prior experience in rare disease oncology or cell and gene therapy.

Where can I find out more

• Follow AstraZeneca on LinkedIn
• Follow Alexion on LinkedIn
• Follow AstraZeneca on Facebook
• Follow AstraZeneca on Instagram
• Learn more about Alexion at

At Alexion you will find a collaborative culture that encourages innovation and a diverse environment where your contributions are valued. You will have the opportunity to be at the forefront of rare disease research and make a meaningful difference in patients lives.

Ready to lead and inspire Apply now and take the first step towards a fulfilling career at Alexion AstraZeneca Rare Disease.

Total Rewards:

The annual base pay (or hourly rate of compensation) for this position ranges from $211854.40 to $317781.60. Our positions offer eligibility for various incentivesan opportunity to receive short-term incentive bonuses equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs paid time off (i.e. vacation holiday and leaves) as well as health dental and vision coverage in accordance with the terms of the applicable plans.

Alexion embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds with as wide a range of perspectives as possible and harnessing industry-leading skills. We believe that the more inclusive we are the better our work will be. We welcome and consider applications to join our team from all qualified candidates regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment) as well as work authorization and employment eligibility verification requirements. Alexion is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment assessment and selection process and may be requested by emailing .

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Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.