SeniorPrincipal Research Associate, LNP DiscoveryPD
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Job Location:
Boston, NH - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
Key Responsibilities:
We are seeking a scientific contributor to lead and execute novel LNP formulation process development activity for the delivery of circular RNA therapeutic at scale. This role will spearhead LNP process development/scale up activity and would be responsible for designing and executing DOE-based formulation process optimization. They would engineer and functionalize LNPs develop analytics for formulation quality control and develop processes to improve formulation at scale. The candidate would have the opportunity to work in a collaboration-oriented role in which they would coordinate with other teams plan and run animal studies with a cross-functional group of scientists and support the growth and career development of junior scientists. The ideal candidate is a chemical engineer/pharmaceutical major with strong LNP formulation optimization and process development experience who is excited by the idea of being a core participant in building an early startup and guiding the scientific vision of the company. They would be engaged in science and driven by our mission to create therapies that help people in ways that are currently impossible.
- Establish execute and document protocols for preparation and characterization of targeted LNP formulations with nucleic acid cargo for in vitro and in vivo studies
- Design and execute DOE-driven studies for LNP composition mixing parameters and process optimization to improve formulation quality stability delivery efficiency and functional activity
- Develop cell and molecular biology assays to assess the delivery efficiency of RNA cargo in mammalian primary cells to facilitate development of therapeutics drugs pipelines
- Assist in the buildout of formulation and analytical capabilities with focus on delivery with nanoparticle technology lyophilization and process development for scale up/production
- Contribute to patent applications related to the delivery technology
- Support technology transfer to CDMOs and Industry Partners
- Foster collaborative relationships across the team and company and engage in a positive and exciting work environment
- Contribute to hiring training and collaborating with scientists (as needed) to formulate characterize develop and support assessment of efficacy
- Plan and coordinate animal studies with in vivo team
- Author technical documents including SOPs for formulation processes and analytical methods maintain diligent records and demonstrate proficiency in scientific communication
- Support high-quality documentations to support regulatory filings
Qualifications :
Minimum Qualifications:
- BS/MS in chemical engineering chemistry pharmaceutical sciences or related field preferably with industry experience of 2-5 years for MS or 5-8 years for BS candidates.
- Strong track record of productivity in nanoparticle research with an understanding of key challenges in nanoparticle/formulation scale-up and translation
- Prior experience in developing lyophilization protocols for nanoparticle formulation and stability testing is a plus
- Technical proficiency with LNP formulation of RNA and analytical assays for particle characterization
- Technical proficiency in developing cell and molecular biology assays to support drug product development
- A minimum of 3-4 years of experience working with lipid nanoparticles for RNA delivery in any capacity
Preferred Qualifications:
- Demonstrated capability in LNP formulation for nucleic acid delivery is must
- LNP process development and scale-up experience is desired
- Experience with tissue-specific targeted delivery of LNP-nucleic acid formulation is a plus
- Demonstrated ability to present complex technical topics to a wide range of audiences with varying technical depth
- Demonstrated proficiency in record keeping and documentations to support SOP generation technology transfer and preferably regulatory filings
Additional Information :
What We Offer:
At our RNA Venture we aim to outmatch the typical benefits you might see in an early startup. We offer:
- Financial security through competitive compensation incentives and retirement plan
- Health care and well-being programs including competitive medical dental vision & medical benefits
- Generous paid time off including vacation sick time holidays and winter shutdown
- 401(k) retirement savings with a generous company match
- Commuter benefits
- Other comprehensive voluntary benefits include but are not limited to pet insurance life insurance employee assistance program (EAP) discount programs and many more
- We continue to optimize our benefits & wellness programs as we grow our organization to make sure they meet our diverse workforce needs
- The stability of a startup backed by a company with a record of strong financial performance year over year
Remote Work :
No
Employment Type :
Full-time
Key Skills
- Laboratory Experience
- Immunoassays
- Mammalian Cell Culture
- PCR
- Biochemistry
- Assays
- Cell Biology
- Research Experience
- Cell Culture
- Molecular Biology
- Flow Cytometry
- Western Blot
About Company
GeneGenieDx is a biotech company founded in 2020 in the Bay Area, California. We aim to discover novel biomarkers and translate them into better clinical diagnostic products. Our current focus is to develop cutting-edge bioinformatics and machine learning algorithms to enable the disc ... View more
