SeniorPrincipal Scientist, Antibody Discovery

Nexagen Search

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profile Job Location:

Rockville, MD - USA

profile Monthly Salary: Not Disclosed
Posted on: Yesterday
Vacancies: 1 Vacancy

Job Summary

Senior/Principal Scientist Antibody Discovery

Rockville MD Full Time


Nexagen Searchis representing a biotechnology company that is hiring for an Senior/Principal Scientist Antibody Discovery to join their research team in Rokville MD. This role will contribute to early-stage discovery programs and will employ molecular biology biochemistry and cell-based techniques to support the development of novel therapeutic candidates


Key Responsibilities

  • Lead discovery-stage research for pipeline therapeutic programs.
  • Identify and validate novel antibody hits using phage/yeast display and/or hybridoma platforms.
  • Develop and execute screening funnels to assess binding selectivity and functional activity across biochemical and cellular assays.
  • Generate expression constructs and produce/purify candidate biologics in mammalian expression systems to support discovery workflows.
  • Characterize antibody candidates through in vitro assays including binding analyses epitope assessment and functional cell-based readouts.
  • Analyze and interpret experimental data to inform hit prioritization lead selection and next-step discovery strategies.
  • Troubleshoot experimental challenges optimize assay conditions and refine discovery tools and methods.
  • Present research findings to internal project teams and represent the program at scientific meetings as needed.
  • Collaborate with cross-functional teamsincluding translational medicine medical sciences CMC and external CRO partnersto advance discovery candidates.
  • May mentor or supervise research associates and scientists contributing to discovery programs.


Core Qualifications & Experience

  • Ph.D. in biochemistry molecular/cell biology immunology pharmacology or related field.
  • Deep expertise in antibody discovery technologies (eg. yeast/phage display hybridoma and/or single b-cell technologies)
  • Hands-on proficiency with gene cloning library construction hit screening and initial lead characterization.
  • Experience with biochemical and cell-based discovery assays such as FACS ELISA Octet and other quantitative binding/functional assays.
  • Working knowledge of mammalian expression systems for producing and purifying screening-stage biologics.
  • Experience running biophysical assays to evaluate KD binding kinetics and epitope interactions.
  • Familiarity with different biologic formats applied in a discovery context.
  • Highly collaborative mindset and ability to work effectively across multidisciplinary discovery teams.
  • Strong written and verbal communication skills including clear presentation of complex scientific data



Recruiter in Charge:Jeff Caskey

Managing Partner




Required Experience:

Staff IC

Senior/Principal Scientist Antibody Discovery Rockville MD Full Time Nexagen Searchis representing a biotechnology company that is hiring for an Senior/Principal Scientist Antibody Discovery to join their research team in Rokville MD. This role will contribute to early-stage discovery programs and ...
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Key Skills

  • Machine Learning
  • Python
  • Data Science
  • AI
  • R
  • Research Experience
  • Sensors
  • Drug Discovery
  • Research & Development
  • Natural Language Processing
  • Data Analysis Skills
  • Toxicology Experience