SeniorPrincipal Scientist, Antibody Discovery
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Job Location:
Germantown, MD - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
Senior/Principal Scientist Antibody Discovery
Germantown MD Full Time
Key Responsibilities
- Lead discovery-stage research for pipeline therapeutic programs.
- Identify and validate novel antibody hits using phage/yeast display and/or hybridoma platforms.
- Develop and execute screening funnels to assess binding selectivity and functional activity across biochemical and cellular assays.
- Generate expression constructs and produce/purify candidate biologics in mammalian expression systems to support discovery workflows.
- Characterize antibody candidates through in vitro assays including binding analyses epitope assessment and functional cell-based readouts.
- Analyze and interpret experimental data to inform hit prioritization lead selection and next-step discovery strategies.
- Troubleshoot experimental challenges optimize assay conditions and refine discovery tools and methods.
- Present research findings to internal project teams and represent the program at scientific meetings as needed.
- Collaborate with cross-functional teamsincluding translational medicine medical sciences CMC and external CRO partnersto advance discovery candidates.
- May mentor or supervise research associates and scientists contributing to discovery programs.
Core Qualifications & Experience
- Ph.D. in biochemistry molecular/cell biology immunology pharmacology or related field.
- Deep expertise in antibody discovery technologies (eg. yeast/phage display hybridoma and/or single b-cell technologies)
- Hands-on proficiency with gene cloning library construction hit screening and initial lead characterization.
- Experience with biochemical and cell-based discovery assays such as FACS ELISA Octet and other quantitative binding/functional assays.
- Working knowledge of mammalian expression systems for producing and purifying screening-stage biologics.
- Experience running biophysical assays to evaluate KD binding kinetics and epitope interactions.
- Familiarity with different biologic formats applied in a discovery context.
- Highly collaborative mindset and ability to work effectively across multidisciplinary discovery teams.
- Strong written and verbal communication skills including clear presentation of complex scientific data
Recruiter in Charge:Jeff Caskey
Required Experience:
Staff IC
Key Skills
- Machine Learning
- Python
- Data Science
- AI
- R
- Research Experience
- Sensors
- Drug Discovery
- Research & Development
- Natural Language Processing
- Data Analysis Skills
- Toxicology Experience
