Postdoctoral Associate Cardiovascular Disease Initiative (CVDI)
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Job Location:
Cambridge, MA - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
General information
Description & Requirements
The candidate will work on NIH funded as well as exploratory academic projects and will conduct experimental research studies at the bench supervise a research associate and contribute to therapeutics project(s) targeting cardiovascular disease.
Example workstreams for projects include: designing high-throughput CRISPR-based screens in hPSC-derived cells characterizing gene functions in hPSC-derived cells and validating potential drug targets. Other tasks include developing assays for small molecule drug discovery generating datasets using single-cell RNA sequencing and validating gene and protein expression with immunofluorescent techniques and in situ hybridization. Additionally work may involve creating and validating in vitro and in vivo disease models and conducting experiments to understand target gene functions.
This is an excellent opportunity for a highly motivated candidate interested in exploring the early stages of drug development in a vibrant atmosphere.
REQUIREMENTS
Ph.D. in Biology (Developmental Molecular Cellular Biology) Genetics Biochemistry or related life science field with 0-2 years of experience in academic setting
At least one first author publication in a basic/mechanistic area of biology
Experience in working with pluripotent stem cells CRISPR genome editing single-cell RNA sequencing cell-based imaging techniques
Hands-on experience in cellular assay development and proficiency with standard assay formats (e.g. flow cytometry imaging luminescence-/fluorescence-based cellular readouts immunohistochemistry) in primary and cultured cells
Experience with cardiac electrophysiology is preferred
Experience with mouse models especially in the cardiovascular field is a plus
Experience with computational skills is a plus
Ability to develop research plans for executing strategy operate and maintain equipment and perform laboratory work with complete independence
Track record of working on complex problems and ability to integrate data from multiple disciplines
Strong interpersonal influencing and collaboration skills to work in a team-oriented matrix environment and the ability to work through conflicts
Outstanding verbal and written communication abilities
Ability to adapt to and effectively manage changes in a fast paced and dynamic environment
A passion and curiosity for science and sense of urgency to find new medicines to benefit patients
The successful candidate will be a results-focused team-oriented creative bench scientist able to excel in a fast-track environment. The candidate must be self-motivated detail-oriented and exhibit strong problem-solving addition the successful candidate should be a clear and effective communicator demonstrating strong interpersonal skills to enable collaboration with project teams peers and management for identifying and achieving research goals.
Required Experience:
IC
Key Skills
- Virology
- Bioinformatics
- Genetics
- R
- Biochemistry
- Cell Biology
- Research Experience
- Spectroscopy
- Cell Culture
- Molecular Biology
- Microscopy
- Research Laboratory Experience
About Company
Broad Institute is a multidisciplinary community of researchers on a mission to improve human health.
