Senior Director, Clinical Practice Liaisons

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) a serious liver disease that can progress to cirrhosis liver failure need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigals medication Rezdiffra (resmetirom) is a once-daily oral liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic inclusive and high-performing culture that values scientific excellence operational rigor and collaboration. To support our continued growth we are strengthening our workforce strategy to ensure we have the right talent at the right time in the right way.

The Sr. Director Clinical Practice Liaison (CPL) is a key field-based leadership position responsible for the strategic and tactical oversight of the CPL team within a defined U.S. region. This individual will play a critical role in managing and developing CPLs ensuring the team executes against the companys medical strategy complies with regulatory and internal policies and delivers scientific value to both internal and external stakeholders.

This position will interface regularly and compliantly with cross-functional colleagues (e.g. Marketing Sales Market Access Clinical Operations HQ Medical Affairs) and external partners including Thought Leaders (TL) healthcare decision-makers and other relevant stakeholders.

Key Responsibilities

• Team Leadership & Development

• Recruit coach and manage performance of regional CPLs

• Foster continuous development through mentoring and training

• Align CPL activities with strategic objectives and tactical plans

• Medical Strategy Execution

• Drive implementation of regional field medical strategies

• Translate national objectives into actionable regionally tailored activities

• Partner with cross-functional teams to integrate field insights into medical planning

• Cross-functional Collaboration

• Collaborate closely with Sales Marketing Market Access and Clinical Operations

• Serve as a field-based liaison for HQ Medical Affairs initiatives

• Contribute to launch readiness and lifecycle management strategies

• Clinical Trial Support

• Collaborate with Clinical Operations to ensure successful study execution based upon recognized needs

• Congress & External Engagement

• Represent Medical Affairs at U.S. medical congresses in a compliant manner

• Coordinate booth planning scientific exchange competitive intelligence and post-conference debriefs

• Strategic Team Building

• Contribute to the design and structure of the U.S. Field Medical team

• Identify evolving business needs and adjust regional capabilities accordingly

• Compliance & Quality

• Ensure all CPL activities comply with company SOPs industry standards and applicable regulations

• Uphold the highest ethical standards in all external engagements

• Travel Requirement

• Willingness to travel 2575% for congresses site visits and stakeholder engagement

Qualifications & Experience

• Advanced degree in a scientific or healthcare discipline (MD PharmD PhD DNP etc.)

• Minimum 5 years of Medical Affairs experience including at least 3 years as an MSL or equivalent (translatable clinical practice experience will be considered)

• Minimum 3 years of people management experience or formal leadership development participation

• In-depth knowledge of clinical medicine and medical research; experience in cardiometabolic health or MASH/NASH preferred

• Proven ability to understand communicate and translate complex scientific information

• Strong knowledge of U.S. healthcare system FDA regulations and medical affairs compliance standards

• Demonstrated cross-functional collaboration project execution and strategic planning skills

• Proficiency in Microsoft Office Suite virtual communication platforms (e.g. Zoom) and CRM systems (e.g. Veeva)

Preferred Attributes

• Strong interpersonal presentation and relationship-building skills

• Adaptable and proactive in a fast-paced evolving environment

• Passion for mentoring team building and field-based medical innovation

#LI-Remote

Madrigals Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

All employees receive equity which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidates qualifications skills education experience business needs and market demands. The base salary range for this position is $262000 - $320000 per year.

All full-time employees receive equity which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits including flexible paid time off medical dental vision and life/disability insurance and 401(k) offerings (i.e. traditional Roth and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance legal services and other addition we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal state and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance please contact

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications merit and business need. Applicants will receive consideration for employment without regard to race ethnicity color religion sex gender identity sexual orientation national origin age disability protected veteran or disabled status or other characteristic protected by applicable federal state or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals Hiring Managers seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigals name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g. fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.

Please also note that any correspondence with regard to employment would come from an authorized email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses with Madrigal misspelled have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to .