Senior Scientist, Protein Analytical Characterization

Discovery Biotherapeutics and Genetic Medicine (BGM) at AbbVie is seeking a highly motivated and experienced scientist to join the Protein Sciences Analytical Team in Worcester MA. This position provides a unique opportunity to directly impact multiple Discovery Research Therapeutic Areas (TAs) and projects by delivering in-depth analytical and functional characterization of biologics and biopharmaceutical productsincluding complex protein antigens monoclonal antibodies multi-specifics and other antibody-like biologics. The ideal candidate will have a strong background in protein analytical characterization with expertise in structural mass spectrometry including hydrogen-deuterium exchange mass spectrometry (HDX-MS) crosslinking mass spectrometry (XL-MS) and covalent labeling mass spectrometry (CL-MS) to characterize epitopes and antigen-antibody interactions. The successful candidate will foster productive collaborations across functional groups and therapeutic areas. This is an excellent opportunity for a motivated scientist to make a significant impact in a collaborative and innovative environment. Join us in bringing innovative medicines to patients!

Key Responsibilities:

• Independently develop and execute high-throughput HDX-MS workflows for epitope mapping analysis of biotherapeutics to support discovery pipeline projects.
• Develop optimize validate and apply innovative structural MS methods (including XL-MS and CL-MS) to characterize epitopes and antigen-antibody interactions.
• Demonstrate scientific initiative and creativity by establishing novel workflows and strategies for the characterization and screening of biologicsincluding non-traditional modalities such as multi-specifics alternative scaffolds and fusion proteinsto support BGM and TA projects.
• Collaborate with external partners CROs or vendors to advance project objectives.
• Analyze document and report data concisely; formulate conclusions and design follow-on experiments based on multidisciplinary inputs.
• Resolve key project challenges by leveraging analytical tools information and technical expertise.
• Communicate project progress data analyses and technical recommendations clearly and promptly to cross-functional teams and senior management.
• Present original research and findings internally and at external scientific conferences; contribute to scientific papers patents and technical reports as an author or co-author.

Qualifications :

• BS or MS or PhD in biology chemistry biochemistry or related field with typically 10-12 (BS) 8-10 (MS) or 0-4 (PhD) years of experience.
• Extensive hands-on experience with HDX-MS platforms (e.g. Trajans LEAP HDX automation) and use of HDX-MS data analysis software (e.g. HDExaminer) for epitope mapping analysis.
• Strong knowledge of structural mass spectrometry technologies including covalent labeling MS and crosslinking MS.
• Advanced proficiency with multiple mass spectrometry platforms (such as Orbitrap and Q-ToF) including MS workflows for protein characterization and expertise with relevant data analysis software.
• Familiarity or experience with coding/programming (e.g. Python R or relevant scripting languages) and in developing automated data workflows or solutions is preferred.
• Familiarity with biophysical and structural methods such as DLS DSF SEC-MALS SEC-SAX X-ray crystallography etc. is a plus 
• Demonstrated theoretical and hands-on expertise in scientific disciplines with a proven ability to rapidly learn and apply new technologies.
• Excellent organizational skills and ability to manage multiple projects and tasks concurrently while meeting deadlines.
• Collaborative goal-driven professional with strong verbal and written communication skills a proactive attitude and success operating in fast-paced cross-functional environments.

Key AbbVie Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.
• Learns fast grasps the essence and can change course quickly when indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment open to suggestions and experimentation for improvement.
• Embraces the ideas of others nurtures innovation and manages innovation to reality.

Position will be filled at level commensurate with extent of education experience and accomplishment - Senior Scientist I or Senior Scientist II

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term incentive programs. 

• This job may be eligible to participate in our long-term incentive programs

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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Work :

No

Employment Type :

Full-time