Senior Scientist I – siRNA, Pipeline Development

At AbbVie we are dedicated to solving some of the worlds most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking for talented passionate and driven individuals to join our Biotherapeutics and Genetic Medicine (BGM) team. As a Senior Scientist in our siRNA group you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care.

Position Overview:

AbbVie is looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department in Cambridge MA. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation identify new methods and techniques and collaborate across functions to support the development of novel RNA-based therapies.

Responsibilities:

• Lead research efforts within a cross-functional team to advance new extrahepatic therapeutic targets for siRNA -based drug discovery.
• Design and execute in vitro and in vivo proof-of-concept studies to assess target engagement validate biological pathways and therapeutic benefits.
• Develop and optimize assays and tools to evaluate siRNA library for their delivery efficacy and off-target risks.
• Contribute scientific leadership and expertise in target biology target selection and pipeline development.
• Work independently and maintain a high level of productivity in the laboratory ensuring efficiency and scientific rigor.
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
• Contribute as a primary author to scientific publications presentations and/or as a primary inventor of patent applications.
• Mentor and support junior scientists within the team.

Qualifications :

Qualifications:

• BS MS or PhD in cell biology molecular biology biochemistry pharmacology or related field with typically 10 (BS) 8 (MS) or 0-3 (PhD) years of experience.
• Demonstrated expertise in siRNA library design and screening for discovery programs.
• Demonstrated experience in assay development optimization troubleshooting and high-throughput implementation for target identification and validation mechanism of action studies siRNA efficacy/biodistribution/stability assessments and biomarker analysis.
• Extensive hands-on experience and techniques for in vitro and in vivo sample process and analysis including cell culture RNA extraction RNA quantification (RT-PCR qPCR ddPCR) next-generation sequencing (NGS) library preparation protein assays (ELISA Western Blot JESS) and flow cytometry.
• Proven capability to interpret complex biological data and derive mechanistic insights that guide program decisions for discovery programs.
• Familiarity with immunological disease models antibody-oligo-conjugates (AOCs) and multi omics approaches is highly desirable.
• Highly self-motivated and capable of thriving in a fast-paced collaborative team environment.
• Strong written and verbal communication skills with experience contributing to technical reports publications or regulatory documentation.

Why AbbVie

AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment opportunities for professional growth and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.

How to Apply:

If you are passionate about advancing RNA-based therapeutics and have a track record of success in cell and molecular biology we encourage you to apply! Please submit your resume and a cover letter outlining your relevant experience and why you would be a great fit for this position.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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Work :

No

Employment Type :

Full-time