Postdoc Immunotherapy Target Discovery using Quantitative Membrane Proteomics

We are looking for a talented and eager postdoctoral researcher to drive a cuttingedge highly collaborative research project in the Voest & Lindeboom laboratories. Combining expertise from both labs you will design novel immunotherapies by integrating innovative proteomics workflows with exciting culture techniques and genetic perturbation assays. You will have access to world-renowned expertise in quantitative proteomics and cancer drug development while analyzing tumor models and primary patient material with the Orbitrap Astral mass spectrometer a gamechanging machine that allows deep quantitative proteome coverage at unprecedented speed and sensitivity.

You will

• Spearhead the development of an innovative proteomics lens to discover unique targets at the cell membrane for next-generation immunotherapies

• Apply these proteomics workflows (with technician support) on genetically modified tumor cell lines and organoids

• Collaborate with clinicianscientists to make a real impact for patients

• Contribute toopen reproducible scienceand publish in highimpact journals

Why this postdoc

• Pioneering expertise: develop unique membrane proteomics tools and apply them in innovative manners to look at drug target discovery in a completely novel manner

• Stateoftheart mass spectrometry: Learn and develop unique workflows with theAstralinstrument to discover druggable protein dynamics

• Translational impact: Projects are embedded in ongoing datarich clinical trials and preclinical programs where experimentalists computational scientists and clinicians closely collaborate to make a real impact for patients youll be supported across the full translational spectrum

• Worldclass ecosystem: NKI offers leading research groups core facilities and a vibrant international community in the heart of Amsterdam

Why the Netherlands Cancer Institute

The Netherlands Cancer Institute (NKI) is a dynamic comprehensive cancer center accommodating over 55 research groups and many state-of-the-art core facilities including imaging cryo-EM flow cytometry proteomics genomics and screening. At the Netherlands Cancer Institute we have a shared goal: providing the best care for every patient and every type of cancer. Here science and health care join forces towards innovation. We keep finding new ways to help people facing cancer on a global scale.

• PhD in quantitative proteomics biochemistry or a closely related field;

• Handson experience in proteomics and data analysis in the context of cancer;

• Hard working highly motivated curious rigorous teamoriented;

• Strong publication record and excellent communication in English;

• Strong drive and inherent excitement to discover novel immunotherapeutic targets withquantitative proteomics.

Your development opportunities and employment conditions

The basic for your employment conditions is in accordance with the CLA Hospitals. You will receive from us:

• Afully funded 3year postdoctoral researcher positionat our top institution with a dynamic and highly international workforce and ample opportunities for personal development. Preferred start date: flexible (ideally soon);

• A contract for a period of three years for 36 hours per week;

• A gross monthly salary between 4.723- and 5.289- based on a 36-hour working week in line with the postdoc scale (FWG55) and depending on your experience and status of PhD finalization;

• 144 holiday hours and 57 hours of Personal Life Budget with full-time employment;

• Annual holiday pay of 8.33% and a fixed end-of-year bonus of 8.33%;

• A travel allowance of 0.23 per km;

• Free parking at the Netherlands Cancer Institute. And with our bicycle plan and discount on public transport we also make it attractive for you to leave the car at home;

• Personal mentorship from established PIs and senior scientists across both labs; clear milestones and career development plans;

• Access tobestinclass instruments tumor models and expert core facilities;

• An active staff association.

Interested

We are curious about your talent! Will you be the one to make a difference in the world of cancer care and research Apply now by using the apply/solliciteer button at the top of the page! Please attach your:

• CV with publications presentations and grades from your bachelor and master

• Cover letter with a list of references

You can only upload two files to the submission system so make sure to merge your transcript of grades and CV into one PDF. Incomplete applications will not be considered.

For further information about the position please contact Joris van de Haar () or Rik Lindeboom ().

Applications will be considered on a rolling basis until a suitable candidate is selected but no later than the 19th of December 2025.