Senior Scientist, Product and Analytical Sciences, Cell Therapy Development Operation

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here uniquely interesting work happens every day in every department. From optimizing a production line to the latest breakthroughs in cell therapy this is work that transforms the lives of patients and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits services and programs that provide our employees with the resources to pursue their goals both at work and in their personal lives. Read more: Summary

As part of the Product and Analytical Sciences group the energetic and self-motivated Sr. Scientist will serve as both a functional program leader or technical lead and as an independent contributor bench scientist to achieve program platform and functional objectives. Where applicable the incumbent may also serve as liaison between the Product Sciences sub-function and Clinical routine testing groups CMC Analytical Strategy Informatics and/or Translational research teams as part of his/her work. Scientifically the incumbent will lead/co-lead the design execution and interpretation of complex experiments/studies related to the development of new/enhanced knowledge regarding CAR T cell products intermediates starting materials as it applies to the manufacturing process and clinical or manufacturing-related investigations within a CMC technical development function.

Duties/Responsibilities

• Lead or co-lead technical development and execution of sensitive bioanalytical assays to characterize cell products intermediates and starting material for internal and external collaborations and deliverables.
• Contribute to the development of biological hypotheses relating to product cellular attributes and their impact on clinical outcomes manufacturing and development of analytical tools.
• Develop and execute complex routine and exploratory characterization assays relating to clinical and manufacturing investigations.
• Contribute to informatics-based correlation studies supporting identification of critical product attributes.
• Support CMC objectives by providing biological and technical knowledge across program and platform strategies for product process and analytical development.
• Efficiently organize data and share findings within and across functional teams.
• Development of programmatic exploratory bench workstreams in the context of product biological understanding using multiomic technologies (e.g. nanostring O-link spectral cytometry seahorse etc.)
• Contribute to mentorship support and empower the development of junior scientists as it relates to both technical and strategic elements of cell therapy product development.
• Ensure proper operation and perform routine maintenance of all laboratory equipment.
• Maintain a safe workplace in accordance with company and OSHA policies/procedures.

Qualifications

• B.S. or M.S. in Immunology Cell/Molecular Biology Biomedical Sciences or related with 7 years academic and/or industrial experience. At least 3 years of industry experience in a cell therapy matrix environment.
• Ph.D. in Immunology Cell/Molecular Biology Biomedical sciences or related discipline with 5 years of academic and/or industrial experience preferably in cell therapy development with proven history of productivity via scientific/technical abstract or article publications.
• Demonstrated leading potential from a functional programmatic level or a SME Technical Senior level.
• Experience with analytical method development for a variety of cell-based bioassays binding assays and/or residual impurities assays are required.
• Advanced knowledge of basic techniques in immunology cell biology and molecular biology is required. Experience with FACS (A5 Lyric Attune cytometers) immunofluorescence-based assays (Incucyte/Imagestream) Luminex PCR and ddPCR cytokine and chemokine detection (ELLA/MSD platforms) cell-based bioassays are highly desired.
• Powerful desire to work within a team structure and to develop mentor and coach team members leading to their success engagement and growth are required.
• Ability to work under minimal technical supervision perform technical strategic and operational tasks independently and lead complex and cross-functional activities.
• Multiomics experience is desirable but not required.
• Experience in mammalian cell culture techniques including isolation of immune cell subsets maintenance and expansion of primary cells and cell lines is required.
• Presentation of data internally and across functions.
• High motivation and drive to acquire new skills and knowledge are desired.
• Willingness to work in a regulated industrial environment.