Post Doctoral Fellow-MSH
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Job Location:
New York City, NY - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
Details of Research Project:
Site-specific intestinal macrophage subtyping in health & inflammatory bowel diseases.
- To decipher site-specific macrophage subtypes in the healthy human intestine. We aim to generate a comprehensive map of macrophage populations focusing on regional differences between the left and right colon and the ileum. Using a multimodal high-dimensional approach including scRNA-seq flow cytometry spatial transcriptomics and multiplexed histology we will analyze intestinal biopsies to characterize macrophage phenotypes spatial localization and transcriptional profiles.
- To decipher IBD-specific macrophage subtypes across inflamed and uninflamed intestinal regions. Building upon the healthy tissue atlas we will applythe same multimodal high-dimensional approach encompassing scRNA-seq flow cytometry spatial transcriptomics and multiplexed histology to characterize site-specific macrophage populations in patients with Ulcerative colitis and Crohns disease.
- To evaluate macrophage profiles as predictive biomarkers of therapeutic response in IBD. We hypothesize that distinct site-specific macrophage signatures are predictive of response to targeted therapy. To test this we will establish a longitudinal patient cohort undergoing anti-IL-23 therapy with intestinal biopsies collected prior to treatment initiation and during therapy.
Responsibilities
Goals/Outcomes of the Research Project:
With our multimodal approach we want to generate a high-resolution atlas of macrophage heterogeneity across distinct intestinal regions establishing a critical baseline for comparison in disease states.
By applying our analyses to patients with inflammatory bowel disease (IBD) will uncover alterations in the macrophage compartment across different intestinal sites during active and quiescent inflammation providing critical insights into the role of macrophages in the pathogenesis of IBD.
In a group of patients with Crohns disease undergoing anti-IL-23 therapy we will characterize the macrophage compartment over time. Integration of these data with clinical and endoscopic outcomes through advanced bioinformatic analyses will assess the potential of macrophage profiles as predictive biomarkers of therapeutic response in IBD.
Qualifications
Technical Duties: (include any protocols)
scRNA-seq flow cytometry spatial transcriptomics and multiplexed histologyperformed on patient samples (intestinal biopsies).
Educational and other Requirements for the position: doctoral degree (MD) research experience communication skills
Experience Required: research experience including scientific publications
Key Skills
- Teacher Coaching
- Public Health
- Google Docs
- Classroom Experience
- Systems Engineering
- Research Experience
- Teaching
- Grant Writing
- Leadership Experience
- Mentoring
- Public Speaking
- Writing Skills
About Company
Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled ... View more
