Scientist or Senior Scientist I, Antibody Oligonucleotide Conjugation (AOC)
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Job Location:
Worcester, MA - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
AbbVie is seeking an innovative scientist to join our Discovery Research team specializing in pre-clinical research and development of antibody oligonucleotide conjugates (AOCs) as well as antibody drug conjugates (ADCs).
Key Responsibilities:
- Synthesis purification and characterization of AOCs and ADCs on mg to gram scale under minimal supervision.
- Development optimization and validation of conjugation protocols specifically for antibody oligonucleotide conjugates.
- Optimization and validation of formulation buffers for AOCs and related bioconjugates.
- Application and refinement of automated techniques for AOC/ADC synthesis and purification.
- Collaboration with cross-functional teams to advance AOC discovery programs from conceptualization to early development.
Qualifications :
- B.S. degree with typically 5-10 M.S. degree with typically 2-8 or PhD with typically 0 years of experience in Analytical Chemistry Biochemistry Molecular Biology or related field.
- Demonstrated hands-on expertise in laboratory-scale protein purification using Hydrophobic Interaction Chromatography (HIC) Size Exclusion Chromatography (SEC) Ion-Exchange (IEX) mixed-mode chromatography and/or affinity chromatography. Experience with GE AKTA FPLC and Unicorn software is preferred.
- Strong experience in the discovery design synthesis and purification of Antibody Oligonucleotide Conjugates (AOC) including familiarity with associated chemistries and analytical methods.
- Hands-on experience with relevant analytical techniques such as HIC-HPLC SEC IEX RP-HPLC and capillary electrophoresis techniques (e.g. CE-SDS icIEF).
- Proven problem-solving skills motivation enthusiasm attention to detail and the ability to thrive in a fast-paced cross-disciplinary team environment.
- Superior written and oral communication skills with a strong record of collaboration and innovation.
Preferred:
- Previous experience with linker chemistry and payload conjugation strategies specific to oligonucleotide therapeutics.
- Experience troubleshooting or optimizing the stability and delivery of antibody-oligonucleotide conjugates.
Position will be filled at level commensurate with extent of education experience and accomplishment Scientist I Scientist II or Senior Scientist I.
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time ofthis posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic locationand we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:
No
Employment Type :
Full-time
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuro ... View more
