Research Fellow Drug Discovery, Molecular Biology & Biochemistry
Research Fellow Drug Discovery, Molecular Biology & Biochemistry
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Job Description
Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
SummaryWill conduct independent and collaborative research contributing to the advancement of knowledge and the development of innovative solutions. The fellow will work under the supervision of the Principal Investigator and collaborate with a team of researchers.
Does this position require Patient Care No
Essential Functions
-Design plan and execute research experiments or projects in alignment with departmental goals.
-Gather analyze and interpret data using appropriate statistical methods and tools.
-Conduct comprehensive literature reviews to inform research direction and methodologies.
-Prepare and publish research findings in peer-reviewed journals and present at conferences and seminars.
-Work collaboratively with faculty students and other researchers contributing to a positive research environment.
-Mentor graduate and undergraduate students providing guidance on research methodologies and techniques.
-Assist in the preparation of grant proposals and funding applications to support ongoing research.
-Prepare periodic reports and documents summarizing research progress and outcomes.
Qualifications
Education
Doctorate Related Field of Study required
Can this role accept experience in lieu of a degree
No
Licenses and Credentials
Experience
Previous Research experience 3-5 years preferred
Knowledge Skills and Abilities
- Demonstrated experience in research techniques methods or research areas relevant to the project.
- Proficient analytical skills proficiency in statistical software and excellent written and verbal communication skills.
- Ability to work independently as well as collaboratively within a team.
- Good interpersonal and communication skills.
Additional Job Details (if applicable)
The Shalhout Lab is recruiting a highly motivated postdoctoral fellow with expertise in small molecule drug discovery molecular biology biochemistry and/or chemistry. Our group is developing innovative approaches to treat cancers by combining cutting-edge experimental biology with computational biology. We are seeking candidates with strong wet-lab skills who are excited to design execute and interpret experiments that drive therapeutic discovery.
ESSENTIAL FUNCTIONS:
- Design and perform biophysical and biochemical assays including protein purification binding/interaction studies cell reporter assays and enzymatic assays. Purify and characterize proteins for structural and functional studies.
- Design and perform proteinprotein and proteinligand interactions (e.g. SPR ITC pull-downs FRET).
- Conduct cell-based functional assays such as reporter assays qPCR and molecular characterization of signaling pathways.
- Carry out molecular biology techniques including cloning mutagenesis and protein expression. Perform mutagenesis and structurefunction studies to map binding sites and mechanisms of action.
- Support hit validation and lead optimization through iterative testing of small molecules.
- Collaborate with medicinal chemistry and computational teams to prioritize candidates and refine drug design.
- Basic understanding of biostatistics
- Analyze and interpret experimental data present findings in lab meetings publications and conferences.
- Collaborate with team members on projects linking experimental data to translational cancer research
EDUCATION AND EXPERIENCE:
PhD in a relevant field (Molecular Biology Biochemistry Biophysics Cancer Biology or related discipline) with a strong track record of peer-reviewed publications in areas such as drug discovery small-molecule therapeutics or translational oncology research.
WORKING CONDITIONS:
Dry and potentially wet lab setting.
Remote Type
Work Location
Scheduled Weekly Hours
Employee Type
Work Shift
EEO Statement:
Mass General Brigham Competency Framework
At Mass General Brigham our competency framework defines what effective leadership looks like by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance make hiring decisions identify development needs mobilize employees across our system and establish a strong talent pipeline.
Employment Type
Full-Time
