Manager, Clinical Pharmacology & Quantitative Pharmacology

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The Manager Clinical Pharmacology & Quantitative Pharmacology (CPQP) position is responsible for individual contribution and/or management support for CPQP data assembly data analyses/visualization modeling/simulation (M&S) and document preparation at all Phases of drug development. The focus of CPQP is to propose and confirm the posology for Alexions medicines. The incumbent will coordinate multiple projects and be encouraged to complete activities independently using internal resources and/or through management of external CROs. The position requires onsite attendance and participation on cross functional drug development teams. Finally this role is central to strengthening the internal CPQP capability within Alexion by contributing to continuous improvement of function technical skills computational infrastructure and the strategic use of M&S methodologies across our programs and disease areas.

Key Responsibilities:

• Leading/contributing to CPQP-related projects including (but not limited to) data assembly/visualization NCA population PK/PKPD analyses clinical trial simulation and other model-based analyses when appropriate.
• Applying CPQP analysis results to make significant contributions to decision making for key development achievements in collaboration with other quantitative fields.
• Vendor management when needed involving initiation and coordination of outsourced CPQP M&S activities.
• Preparing/overseeing preparation of CPQP documents for use in internal CPSS/CPQP discussions decision making presentations regulatory submissions.

Essential Education Experience & Skills:

• PhD or equivalent degree/experience (totalling 10 years) in a quantitative science
• 1 years experience in the health or pharmaceutical industry or another industry such as engineering math/statistics or computer science.
• Excellent hands-on experience in R (or other data processing/visualization software) and a good understanding of data structures.
• Good hands-on experience in Matlab or Julia or another programming language useful for performing QSP PBPK and AI tasks.
• Well versed at plotting complex data to identify trends important for drug development.

Desired Experience & Skills:

• Experience in the application of mathematical modeling to hematology nephrology and/or neurological disorders and rare diseases.
• Familarity with one or more: Python Java NONMEM (or other nlme software).

Date Posted

Closing Date

Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment training compensation promotion and other terms and conditions of employment based on race color religion creed or lackthereof sex sexualorientation age ancestry national origin ethnicity citizenship status marital statuspregnancy (including childbirth breastfeeding or related medical conditions) parental status (including adoption or surrogacy) military status protected veteran status disability medical condition gender identity or expression genetic information mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin aninteractive dialogue with Alexion regarding an accommodation please contact . Alexion participates in E-Verify.