Thesis work, 60 credits Pioneering Cyclic siRNA Design at AstraZeneca Gothenburg
Thesis work, 60 credits Pioneering Cyclic siRNA Design at AstraZeneca Gothenburg
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Job Description
Are you ready to shape the future of oligonucleotide therapeutics Join the Oligonucleotide Chemistry & Targeted Delivery team at AstraZeneca Gothenburg for a one-year masters thesis focused on developing next-generation siRNA molecules!
About AstraZeneca:
AstraZeneca is a global science-led patient-centered biopharmaceutical company focusing on discovering developing and commercializing prescription medicines for some of the worlds most serious diseases. But were more than a global leading pharmaceutical company. At AstraZeneca were dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit.
About the Opportunity:
As a Thesis Worker at AstraZeneca youll find an environment thats full of unique opportunities and exciting challenges. Here youll have the opportunity to pursue your areas of interest whilst equally developing a broad skillset and knowledge base to get the best out of your experience. Youll be working on meaningful projects to make an impact and deliver real value for our patients and our business.
Thesis work description:
Background:Modern siRNA medicines are transforming the treatment of chronic and rare diseases by enabling longer-lasting effects convenient dosing schedules and multi-gene targeting. Building on recent breakthroughsincluding the approval of self-injectable siRNA drugsAstraZeneca is exploring innovative ways to further improve their pharmacokinetic and pharmacodynamic profiles. This thesis project centers on designing synthesizing and evaluating cyclic siRNA constructs to achieve enhanced drug stability and extend therapeutic action.
What youll do:You will work hands-on in AstraZenecas state-of-the-art labs synthesizing and modifying oligonucleotides. Using novel chemical techniques you will lock siRNA strands into single cyclic structures test diverse linkers and conjugation strategies (GalNAc lipids peptides) and assess their thermal biophysical and gene-silencing properties. The project will also explore multi-gene silencing by combining multiple sequences in one molecule.
Your impact:The main goal is to develop cyclic siRNA molecules that outperform traditional linear drugs in both stability and dosing potentially enabling once-yearly injections for patients. Your work will directly advance targeting methods for chronic diseases and open new doors for supramolecular oligonucleotide design.
Structure:
- Duration: 2026
- Credits: 60
Essential Requirements:
- Enrolled in a Masters program within Chemistry.
- Lab experience.
- Excellent communication in English.
So whats next
Apply today and take the chance to be part of making a difference making connections and gaining the tools and experience to open doors and fulfil your potential. We cant wait to hear from you!
We welcome your application as soon as possible but ahead of the scheduled closing date 5th of October 2025. In the event that we identify suitable candidates ahead of the scheduled closing date we reserve the right to withdraw the vacancy earlier than published.
Date Posted
15-sep.-2025Closing Date
05-okt.-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Employment Type
Full-Time
