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Our laboratory conducts 2-photon laser-scanning microscopy imaging of neuronal activity in awake mice with a focus on mouse models of genetic risks for developing schizophrenia. Preference will be given to applicants who have received their Ph.D. degrees in behavioral neuroscience or related fields within the last 3 years and have experience in computational neuroscience and data mining using machine learning methods.
The successful candidate will lead an independent research project dedicated to identifying abnormal behavior and neuronal activities in circuits of murine models of 22q11.2 and 3q29 deletion syndromes two rare conditions that confer the highest genetic risks of schizophrenia.
Qualifications:
PhD in neuroscience or related fields
DeepLabCut or similar methods
Demonstrated hands-on experience with 2-photon imaging techniques
Experience analyzing time-series data preferably from neuroimaging or behavioral studies
Excellent communication skills and ability to work in a collaborative environment
The laboratory is equipped with Mini-2p (Thorlabs) for imaging neuronal activity in behaving animals two 2-photon mesoscopes (Thorlabs) for imaging large cortical and subcortical areas in awake head-fixed animals two 2-photon microscopes for single-cell electrophysiological experiments in brain slices (Chun et al Science 2014; Blundon et. al. Science 2017; Davenport et al. Cell 2022; Bayazitov et al. Cell Reports 2024 Patton et al. Cell Reports 2024; Eom et al Nature Communications 2024).
The successful candidate will join a diverse team of researchers whose efforts are directed toward understanding behavior at the levels of neural circuits individual neurons synapses and molecules. The laboratory is part of the Department of Developmental Neurobiology which houses specialized departmental shared resources including an integrated support structure for rodent behavior testing brain organoids in vivo and ex vivo cellular imaging bioinformatics production of genetically engineered animal models single-cell profiling and advanced image processing and addition numerous institutional shared resources and core facilities support the laboratory by providing expertise and state-of-the-art technologies.
St. Jude Childrens Research Hospital offers an excellent salary and benefits package and is an equal opportunity employer. Interested applicants should send their CVs and the names and addresses of 3 references to:
Stanislav Zakharenko M.D. Ph.D.
Department of Developmental Neurobiology MS 322
St. Jude Childrens Research Hospital
262 Danny Thomas Place
Memphis TN 38105
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Required Experience:
IC
Full-Time