Post Doc Fellow Internal Medicine (Pulmonary)

Department:

SOM KC Internal Medicine - Pulmonary Critical Care and Sleep Medicine

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Pulmonary and Critical Care Medicine

Position Title:

Post Doc Fellow - Internal Medicine (Pulmonary)

Job Family Group:

Professional Staff

Job Description Summary:

The Postdoctoral Fellow in Dr. Rene Corteses Lab in the Division of Pulmonary Critical Care and Sleep Medicine at the University of Kansas Medical Center is focused on unraveling the epigenetic mechanisms involved in vascular dysfunction associated with cardiopulmonary complications with a current emphasis on understanding how Obstructive Sleep Apnea (OSA) contributes to vascular senescence and pulmonary vascular remodeling.
This translational research program utilizes a combination of epigenomic genomic proteomic imaging and physiological techniques in both in vitro and in vivo systems. The lab is particularly interested in how epigenetic alterations influence disease progression in pulmonary and vascular tissues and seeks to identify molecular targets for potential therapeutic intervention.

Job Description:

Job Duties Outlined:

Research Overview:
Design and conduct experiments and interpret data under the mentorship of the Principal Investigator (PI).

• Lead and execute innovative research projects focused on the epigenetic mechanisms underlying vascular dysfunction in cardiopulmonary disease with an emphasis on OSA-induced vascular senescence.

• Independently design optimize and troubleshoot advanced molecular and cellular biology experiments.

• Perform RNA/DNA isolation from cells tissues and biofluids; conduct real-time and endpoint PCR; and carry out protein-based assays.

• Execute immunohistochemistry immunofluorescence in-situ hybridization and histological analyses.

• Maintain and utilize primary and immortalized cell cultures under sterile conditions.

• Perform imaging using light fluorescence and confocal microscopy.

Expectations:
The Postdoc will be expected to complete research projects under the guidance of the faculty mentor record and interpret the results of their experiments in an (electronic) laboratory notebook prepare publication-quality manuscripts (including figures and tables) and publish in peer-reviewed literature.

• Utilize and manage in vivo models to investigate molecular and physiological mechanisms of OSA and cardiovascular dysfunction.

• Conduct animal procedures tissue harvesting histological preparations and specialized physiological measurements.

• Apply advanced techniques such as echocardiography catheterization and myography (as experience permits).

• Analyze and interpret complex datasets using appropriate statistical and computational tools.

• Organize synthesize and translate experimental findings into meaningful conclusions aligned with the labs research objectives.

• Draft high-quality manuscripts for peer-reviewed journals and contribute to grant applications.

• Prepare and deliver presentations at laboratory meetings departmental seminars and scientific conferences.

• Collaborate with clinical coordinators basic science investigators and core facility staff to advance multidisciplinary research projects.

• Provide guidance and mentorship to graduate students research assistants and junior lab members.

• Support team members with troubleshooting and experimental design recommendations.

• Assist in the preparation of research proposals including literature reviews preliminary data figures and methodological sections.

• Contribute to the strategic planning of future research directions based on current findings.

Compliance:
Attend and maintain compliance on all orientation and training sessions designated by the University and the Department understand and follow IACUC and biosafety protocols and attend departmental seminars and regular lab meetings.

• Ensure compliance with biosafety BSL-2 pathogen handling and institutional safety protocols.

• Maintain rigorous and accurate documentation of all experiments datasets and protocols in compliance with institutional and funding agency requirements.

This job description is not designed to cover or contain a comprehensive listing of activities duties or responsibilities that are required of the employee for this job. It is only a summary of the typical functions of the job not an exhaustive list of all possible job responsibilities tasks duties and assignments. Furthermore job duties responsibilities and activities may change at any time with or without notice.

Required Qualifications:

Education:

• Ph.D. in Biological Sciences Molecular Biology Biomedical Sciences or a related field.

This position requires a formal degree in the cited discipline area(s) to ensure that candidates have advanced knowledge analytical skills and professional competencies necessary to perform the duties of the position. The level of degree is commonly recognized as the standard qualification for similar roles in the public and private sector ensuring that the university remains competitive with industry aligned practices enhances collaboration with external partners and supports the delivery of services and programs that meet professional and market-driven expectations.

Work Experience:

• Experience in cell culture microscopy and pre-clinical animal models.

• Experience with biochemistry imaging techniques and experiments design.

• Demonstrated record of scientific productivity (i.e. peer-reviewed publications).

Preferred Qualifications:

Work Experience:

• Experience with biochemical and molecular techniques including immunohistochemistry protein/DNA/RNA assays and sterile cell culture.

• Experience with BSL-2 pathogens and compliance standards.

• Animal handling experience with expertise in echocardiography catheterization and myography.

• Experience in models of cardiovascular or pulmonary dysfunction.

• Experience studying vascular dysfunction or cardiopulmonary disease models.

Skills:

• Attention to detail.

• Organization.

• Communication.

• Multitasking.

• Time management.

• Collaboration.

• Critical thinking.

• Analytical skills.

Required Documents:

• Resume/Curriculum Vitae

• Cover Letter describing your research background interests and career goal

Comprehensive Benefits Package: