Post Doctoral Fellow - Lab of Dr. Hou

Job Details

Job Description

Nanopore direct RNA sequencing is currently the state-of-the-art technology to map RNA modifications. Our position is NIH-funded at Thomas Jefferson University Philadelphia USA which offers intellectual growth and the potential for long-term stability.

For more information please see the following publications and our website:

Tavakoli S Nabizadeh M Makhamreh A Gamper H Rezapour NK Hou YM Wanunu M Rouhanifard SH. (2023) Semi-quantitative detection of pseudouridine modifications and type I/II hypermodifications in human mRNAs using direct long-read sequencing. Nat Commun 14(1):334. PMID:; PMCID:PMC9852470

Gamper H McCormick C Makhamreh A Wanunu M Rouhanifard SH Hou YM. (2023) Enzymatic synthesis of RNA standards for mapping and quantifying RNA modifications in sequencing analysis. Methods in Enzymology Academic Press PMID:

Hou YM Nakano Y. (2024) Breaking the deadlock in genetic code expansion. Invited for an article in News & Views commenting on the paper in Nature Adding aa-disubstituted and b-linked monomers to the genetic code of an organism. Nature Chem Biology PMID: . YI Rebolledo LP Skelly E de Freitas Saito R Wei H Lilley D Stanley RE Hou YM Yang H Sztuba-Solinska J Chen SJ Dokholyan NV Tan C Li K He X Zhang X Miles W Franco E Binzel DW Guo P Afonin KA (2024) Cracking the code: Enhancing molecular tools for progress in nanotechnology. ACS Applied Bio Materials PMID: ; PMCID: PMC.

Masuda I Hou YM. (2024) A tRNA modification pattern that facilitates interpretation of the genetic code. Submitted to Frontier in Microbiology PMID: ; PMCID: PMC.

Namani S Kavetsky K Lin CY Maharjan S Gamper H Li NS Piccirilli J Hou* YM Drndic* M. (2024) Unraveling RNA conformation dynamics in mitochondrial encephalomyopathy lactic acidosis and stroke-like episode syndrome with solid-state nanopores. ACS Nano PMID: DOI:10.1021/acsnano.4c04625

Maharjan S Gamper H Yamaki Y Christian T Henley RY Li NS Suzuki T Suzuki T Piccirilli JA Wanunu M Seifert E Wallace DC Hou YM. (2024) Post-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology. Nature Commun 15(1):9008 doi: 10.1038/s418-x; PMID: ; PMCID:PMC

Makhamreh A Tavakoli S Fallahi A Kang X Gamper H Nabizadehmashhadtoroghi M Jain M Hou YM Rouhanifard SH Wanunu M. (2024) Nanopore signal deviations from pseudouridine modifications in RNA are sequence-specific; quantification requires dedicated synthetic controls. Sci Rep. 14(1): 22457. DOI:10.1038/s414-9; PMID: ; PMCID:PMC.

Nakano Y Gamper H McGuigan H Maharjan S Sun Z Yigit E Grunberg S Krishnan K Li NS Piccirilli JA Kleiner R Nichols N Hou YM. (2025) Genome-wide profiling of tRNA modifications by Induro-tRNAseq reveals coordinated changes. Nat Commun PMID: ; PMCID: PMC ; DOI: 10.1038/s418-1.

Fanari O Tavakoli S Qiu Y Makhamreh A Nilan K Akeson S Meseonznik M McCormick CA Block D Gamper H Jain M Hou YM Wanunu M Rouhanifard SH. (2025) Probing enzyme-dependent pseudouridylation using direct RNA sequencing to assess neuronal epitranscriptome plasticity. Cell Systems 2025 Mar 18:101238 doi: 10.1016/.; PMID:

send a cover letter CV and contact information of three references to:

Ya-Ming Hou

Professor of Biochemistry and Mol Biology

Email:

Thomas Jefferson University 233 S. 10thStreet BLSB 220

Philadelphia PA 19107 USA

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Nationally ranked Jefferson which is principally located in the greater Philadelphia region Lehigh Valley and Northeastern Pennsylvania and southern New Jersey is reimagining health care and higher education to create unparalleled value. Jefferson is more than 65000 people strong dedicated to providing the highest-quality compassionate clinical care for patients; making our communities healthier and stronger; preparing tomorrows professional leaders for 21st-century careers; and creating new knowledge through basic/programmatic clinical and applied research. Thomas Jefferson University home of Sidney Kimmel Medical College Jefferson College of Nursing and the Kanbar College of Design Engineering and Commerce dates back to 1824 and today comprises 10 colleges and three schools offering 200 undergraduate and graduate programs to more than 8300 students. Jefferson Health nationally ranked as one of the top 15 not-for-profit health care systems in the country and the largest provider in the Philadelphia and Lehigh Valley areas serves patients through millions of encounters each year at 32 hospitals campuses and more than 700 outpatient and urgent care locations throughout the region. Jefferson Health Plans is a not-for-profit managed health care organization providing a broad range of health coverage options in Pennsylvania and New Jersey for more than 35 years.

Jefferson is committed to providing equal educational and employment opportunities for all persons without regard to age race color religion creed sexual orientation gender gender identity marital status pregnancy national origin ancestry citizenship military status veteran status handicap or disability or any other protected group or status.

Benefits

Jefferson offers a comprehensive package of benefits for full-time and part-time colleagues including medical (including prescription) supplemental insurance dental vision life and AD&D insurance short- and long-term disability flexible spending accounts retirement plans tuition assistance as well as voluntary benefits which provide colleagues with access to group rates on insurance and discounts. Colleagues have access to tuition discounts at Thomas Jefferson University after one year of full time service or two years of part time service. All colleagues including those who work less than part-time(including per diemcolleagues adjunct faculty and Jeff Temps) have access to medical (including prescription) insurance.

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