Research Technician - Department of Cardiovascular SciencesGrade 4

Position Details

Department of Cardiovascular Sciences School of Medical Sciences College of Medicine and Health

Location: University of Birmingham Edgbaston Birmingham UK

Full time starting salary is normally in the range 27166 to 28768 with potential progression once in post to 32145

As this vacancy has limited funding the maximum salary that can be offered is Grade 4 salary 27166.

Full Time Fixed Term contract up to April 2029

Closing date: 7th September 2025

Interview date: 15th September 2025

Background

This full-time position (35 hours/week) within the College of Medicine and Health School of Medical Sciences Department of Cardiovascular Sciences and will be supporting the researchof Dr Alex Slater.

The post is funded for 4 years by BHF to study novel regions of platelet receptor GPVI that can be targeted to treat thrombosis. This will be achieved through a combination of structural biology and site directed mutagenesis to find regions of GPVI that are critical for its activation in the membrane. Protein constructs of these critical regions will then be made and used to raise nanobodies with the ability to inhibit GPVI function. These nanobodies will be characterised in a range of assays to determine their inhibitory properties with the aims of developing them for further use as antithrombotic agents.

Role Summary

You will provide technical support for research activities as required utilising your technical skills and a wide range of techniques. You will also be expected to ensure your working area is safe and support others in following health and safety instructions. You may need to operate out of normal working hours to accommodate research order to flexibly use resource you may be given the opportunity to work in different areas of the department or wider University.

Main Duties

The role holder will provide support for the research undertaken by Dr Slater using a variety of techniques to include but not exclusively:

• Protein expression using mammalian and bacterial culture systems.
• Protein purification using affinity chromatography and size exclusion chromatography.
• Molecular biology techniques focussing on site directed mutagenesis mini prep and maxi prep DNA extraction.
• Protein-protein interaction assays including surface binding assays (ELISA).
• Characterisation of antibodies or antibody derived fragments (i.e. nanobodies).
• Carry out techniques and experimental procedures as required by research staff students and Principal Investigators designed to contribute to a specific research project or projects.
• You will be expected to resolve problems in your area of expertise but also to recognise when problems need to be referred to more senior staff.
• You will need to maintain accurate records of all techniques and experimental procedures carried out and of any other research activities you may be involved in including results.
• Comply with any legislation relevant to the area of research/activity.
• Comply with the Standard Operating Procedures for the activity.
• Demonstrate techniques to other staff and/or students on the area of expertise as required.
• You will contribute to internal and external audit procedures and to regulatory inspections.

Health and Safety

• You will be expected to uphold compliance with all University and local Health & Safety policies including risk assessments and manual handling reporting any breaches or non-compliance to the relevant manager.
• You will be expected to manage the safe handling and disposal of all materials used in research laboratories including hazardous materials.
• If required assist or prepare risk assessments and keep these up to date.
• You will need to maintain all records as appropriate.
• Carry out regular maintenance processes as appropriate.

Administrative duties

• You may be required to assist with PAT testing and calibration of equipment and with updating equipment inventories.
• Maintain stocks of consumables and if necessary creating purchase order requisitions.
• Receipt and correct storage of consumables and chemical reagents.
• Ensure that the facilities are maintained in a clean functional and safe condition reporting any problems.
• Reporting any problems with equipment or services which cannot be resolved to the line manager as appropriate.
• Adopt a proactive attitude to assisting with and implementing carbon reduction and energy saving measures where practicable.
• Supports equality and values diversity moderates own behaviour to avoid unfair discriminatory impact or bias on others.
• Any other duties commensurate with the grade and skill base of the post holder.

Required Knowledge Skills Qualifications Experience

• NVQ BTEC/ONC at level three or equivalent level three qualification and specific relevant experience in an appropriate subject.
• GCSE level 2 (A*- C/4-9) or equivalent level 2 qualification in mathematics and English.
• Practical experience of the above techniques and a working knowledge of Good Laboratory Practice.
• Experience of working in a laboratory based teaching or research environment; or be able to demonstrate the capability to participate in research projects.
• Ability to organise and manage own workload after consultation with manager.
• Familiarity with the use of a wide range of general laboratory equipment e.g. balances pH meters autoclaves glass washing machines microscopes.
• Proactive approach to Health and Safety matters together with the communication skills to interact with a range of people including students.
• Ability to be flexible to meet deadlines.
• The post holder will be fully familiar with the safe handling and storage of laboratory materials.
• Good IT skills having a familiarity with both Windows and/or Apple Macintosh OS will be advantageous.
• Understands the importance ofequality and diversity in the workplace.
• Ability to identify and respond to equality and diversity issues in line with relevant policies and procedures.

Dimensions

You will have no direct line management responsibility (other than occasional instructions to other staff) and no budget to manage.

Planning and Organising

You will be able to schedule and organise your own work within the priorities and requirements for the area.

Problem Solving and decision making

You will deliver a level of service as agreed carrying out daily research support as required. You will be expected to assist in analysis and interpretation of research results.

Internal and External relationships

This role is primarily concerned with advising and supporting research staff.

Further particulars can be foundhere

Informal enquiries to Carol Benham email: or Dr Alex Slater email: .

We believe there is no such thing as a typical member of University of Birmingham staff and that diversity in its many forms is a strength that underpins the exchange of ideas innovation and debate at the heart of University life. We are committed to proactively addressing the barriers experienced by some groups in our community and are proud to hold Athena SWAN Race Equality Charter and Disability Confident accreditations. We have an Equality Diversity and Inclusion Centre that focuses on continuously improving the University as a fair and inclusive place to work where everyone has the opportunity to succeed. We are also committed to sustainability which is a key part of our strategy. You can find out more about our work to create a fairer university for everyoneon our website.