Post Doctoral Fellow-Sickle Cell, Dr. Francesca Vinchi
Post Doctoral Fellow-Sickle Cell, Dr. Francesca Vinchi
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Job Description
Discover Your Career at Emory University
Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future. We welcome candidates who can contribute to the excellence of our academic community.
Description
POSITION OVERVIEW:
- Title: Postdoctoral Fellow in the Department of Hematology and Oncology Emory University School of Medicine
- Location: Aflac Cancer and Blood Disorders Center Health Sciences Research Building I Atlanta GA
- Lab/PI: Dr. Francesca Vinchis lab
- Focus: Investigating heme/iron dyshomeostasis in hematologic disorders (with a focus on sickle cell disease) and its contribution to disease pathogenesis and pathophysiology using translational models and omics/single-cell technologies.
The position is responsible for research aimed at investigating mechanisms of heme/iron-driven toxicities in sickle cell diseases. Under the guidance of the PI Dr. Vinchi the research fellow will study the impact of heme and iron overload on the pathophysiology of sickle cell diseases as well as the pathogenesis of other human hematological diseases. The candidate will perform cutting-edge research that integrates hematology and immunology with novel therapies using innovative technologies and approaches including classic molecular cellular and biochemical techniques as well as modern imaging techniques RNA sequencing and metabolomics at bulk and single cell levels bioinformatics and preclinical in vitro and in vivo models.
RESEARCH FOCUS AND GOALS:
- Understanding heme/iron-driven molecular mechanisms of altered hematopoiesis immune activation and vascular dysfunction and their implications in the pathogenesis and pathophysiology of sickle cell disease and other hematologic diseases.
- Studying heme/iron metabolism hematopoiesis and immunology in inherited or acquired anemias.
- Applying cutting-edge methods including cell culture mouse modeling and in vivo/ex vivo mouse experiments flow cytometry scRNA-seq metabolomics real-time PCR western blotting in vitro hematopoietic assays.
- Modifying heme/iron-related pathways through therapeutic compounds in collaboration with pharmaceutical/industry partners.
- Contributing to translational science helping to shape mechanistic biological insights that feed into new clinical trials in the field of hematology.
RESPONSIBILITIES:
- Work independently on a research project under the supervision of the Lab Head
- Daily molecular bench work
- Working with mice and performing in vivo experiments on a regular basis
- Managing mouse colonies including genotyping
- Working with mammalian cell culture (primary and cell lines) including human bone marrow and peripheral blood cells.
- Maintaining lab files related to the general lab and research experiments.
- Reporting research progress while maintaining up to date knowledge of literature in relevant fields.
- Summarizing experimental data assist in drafting figures results and methods for presentations publications and grants.
JOB DESCRIPTION:
- Helps design and conduct research within a specified field while receiving advanced training from a designated Principal Investigator to enhance professional skills and research independence needed for pursuit of a career.
- The specific area of research in which the trainee is mentored is determined by the department and laboratory of the Postdoc.
- Designs and evaluates experiments.
- Develops new ideas that promote current research.
- Prepares and publishes scientific manuscripts under the direction of the Principal Investigator.
- May be responsible for operation of specific equipment.
- May teach techniques to others train and supervise research staff.
- Positions are temporary appointments as a research trainee.
- The initial appointment is for one year renewal expected if progress is satisfactory and funds are available.
- Appointments cannot exceed five years.
MINIMUM QUALIFICATIONS:
- A doctoral degree or equivalent (Ph.D. M.D. ScD. D.V.M. DDS etc) in an appropriate field.
- Excellent scientific writing ability and strong oral communication skills.
- The ability to work effectively and collegially with colleagues.
- Additional qualifications as specified by the Principal Investigator.
PREFERRED QUALIFICATIONS:
- PhD or MD/PhD in hematology cell biology molecular biology or related field.
- Prior experience with mouse models basic molecular biology techniques and cell-based assays
- Strong record of productivity and peer-reviewed publications.
- Excellent communication skills and ability to work in a collaborative research environment.
- Ability to perform experiments independently under PIs guidance provide input into experimental design identify problems in a timely manner evaluate options and implement solutions.
- Mentored training in a NIH-funded high-impact research program.
- Access to unique resources at Emory School of Medicine including state-of-the-art core facilities clinical collaborators and partnering institutions like Georgia Tech.
- Participation in career development programs and academic training workshops at Emory and Childrens Healthcare of Atlanta.
- Opportunity to work on industry-relevant translational projects with real patient samples and preclinical models.
- Collaboration with oncologists hematologist and drug developers.
Submit your application online via Emory Careers including:
- Curriculum Vitae
- Cover letter outlining your research interests
- Contact information for three referees
- Inquiries can be sent directly to
NOTE: Position tasks are required to be performed in-person at an Emory University location; working remote is not an option. Emory reserves the right to change this status with notice to employee.
Additional Details
Emory is an equal opportunity employer and qualified applicants will receive consideration for employment without regard to race color religion sex national origin disability protected veteran status or other characteristics protected by state or federal law. Emory University does not discriminate in admissions educational programs or employment including recruitment hiring promotions transfers discipline terminations wage and salary administration benefits and training. Students faculty and staff are assured of participation in university programs and in the use of facilities without such discrimination. Emory University complies with Section 503 of the Rehabilitation Act of 1973 the Vietnam Era Veterans Readjustment Assistance Act and applicable executive orders federal and state regulations regarding nondiscrimination equal opportunity and affirmative action (for protected veterans and individuals with disabilities). Inquiries regarding this policy should be directed to the Emory University Department of Equity and Civil Rights Compliance 201 Dowman Drive Administration Building Atlanta GA 30322. Telephone: (V) (TDD).
Emory University is committed to providing reasonable accommodations to qualified individuals with disabilities upon request. To request this document in an alternate format or to request a reasonable accommodation please contact the Department of Accessibility Services at (V) (TDD). Please note that one weeks advance notice is preferred.
Employment Type
Full-Time
