Director, Translational Medicine Lead, Hematology

Job Title: Translational Medicine Lead Haematology R&D
Location: Gaithersburg MD

At AstraZeneca we pride ourselves on crafting a collaborative culture that champions knowledge-sharing ambitious thinking and innovation ultimately providing employees with the opportunity to work across teams functions and even the globe.

Recognizing the importance of individualized flexibility our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office is purposely designed with collaboration in mind providing space where teams can come together to strategize brainstorm and connect on key projects.

Our dedication to sustainability is also central to our culture and part of what makes AstraZeneca a great place to work. We know the health of people the planet and our business are interconnected which is why were taking ambitious action to tackle some of the biggest challenges of our time from climate change to access to healthcare and disease prevention.

Introduction to Role:

Within Haematology R&D we are dedicated to advancing science to deliver life-changing medicines to patients in need. Our combination-focused pipeline harnesses the power of multiple scientific platformsimmuno-oncology tumor drivers and resistance DNA damage response antibody-drug conjugates cell therapy and epigeneticsto address unmet needs in haematological cancers. Our commitment to scientific discovery and collaboration drives our mission to eliminate cancer as a cause of death managing the value chain from discovery to late-stage development.

Translational Medicine (TM) transforms haematological cancer biology into actionable insights for therapeutic development and clinical decision-making within the Oncology space. Operating within the Haematology R&D division TM is responsible for delivering innovative strategic biomarker studies to support Haematology & Oncology project teams to make decisions. The TM team collaborates closely with preclinical bioscience and discovery clinical development and precision medicine & biosamples functions. TM provides robust scientifically driven biomarkers for all Haematology projects covering leukemia lymphoma and myeloma. This includes assay development technical validation and biomarker analysis for clinical samples. TM conducts translational research across early and late-phase clinical engagements integrating advanced biomarker strategies to enhance therapeutic outcomes.

Accountabilities:

• Develop and implement comprehensive translational science strategiesencompassing patient selection pharmacodynamics mechanism of action and mechanism of resistance for preclinical therapies through Phase 3 clinical studies
  • Deliver robust biomarker strategies and datafor clinical studies based on best available science and technologies
  • Accountable for development and deploymentof fit for purpose translational assays both internally and or externally
  • Measure target engagement pharmacodynamic biomarkers and mechanism of actionreliably and quantifiably to inform clinical decisions.
  • Explore mechanisms of resistance of therapies and deliver data to guide decision making
• Implement translational strategiesinto clinical studies including sample collection protocols laboratory manuals clinical study protocols and biomarker analyses in oncology and haematology studies.
• Analyze target expression cancer pathway interactions feedback mechanisms and tumor microenvironment featuresin clinical samples to guide rational drug combination strategies across oncology and haematology programs.
• Contribute to and ensure qualityof Translational Medicine clinical study reports data reviews and interpretations presentations scientific publications and recommendations to development teams and management for strategic decision-making.
• Collaborate with cross-functional teamsincluding Oncology Research Translational Medicine clinical development clinical operations and product development teams to facilitate appropriate incorporation of translational medicine strategies for molecules in early phases of development.
• Influence translational strategyacross the AstraZeneca portfolio to maximize scientific impact and therapeutic outcomes.
• Lead and manage internal and external research collaborationsin areas of clinical technologies and oncology translational research to advance portfolio objectives.

Essential Skills/Experience:

• PhD and /or MD with experience in oncology drug development required.
• 5 years of experience in drug development in pharmaceutical or biotech industries
• In-depth knowledge of Immunology Haematology-Oncology disease area biology and translational science.
  • Prefer expertise in myeloma leukemia and lymphoma.
• Highly desire experience with T cell engagers antibody-drug conjugates and cell therapy modalities is preferred
• Proven communication presentation and influencing skills.
• Highly developed problem solving and risk management skills.
• Ability to drive manage execute and deliver results for complex multi-functional projects.
• Highly developed collaborative working skills.
• Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca.
• Proven ability to motivate and develop others.

Where can I find out more

• Our Social Media Follow AstraZeneca on LinkedIn AstraZeneca on Facebook AstraZeneca on Instagram US Footprint: Powering Scientific Innovation - YouTube

Total Rewards:
The annual base pay for this position ranges from $172788.80 to $ 259183.20.Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime pay offered may vary depending on multiple individualized factors including market location job-related knowledge skills and addition our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles)to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an at-will position and the Company reserves the right to modify base pay(as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors.

AstraZenecais an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment assessment and selection process and may be requested by emailing.

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Date Posted