Principal Investigator I, Discovery Biology
Principal Investigator I, Discovery Biology
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Job Description
SUMMARY
Brii Bio is seeking a highly skilled biologist for our growing drug discovery team. The individual will be working in our state-of-the-art wet laboratory space Shanghai China. The successful candidate will lead and conduct experimental biology studies in all phases of exploratory and discovery biology. The position will require a diverse skill set and knowledge base to include cell-free biochemical assays cell-line studies as well as primary cell biology. A deep understanding of in vivo pharmacology and in vitro to in vivo translation into preclinical species as well as human studies will be important. This role will be part of an experienced discovery team and offers the opportunity to develop new skills and obtain experience and expertise as part of a multidisciplinary global pharmaceutical research team. The individual will be accountable to identify and develop assays and methods to characterize novel biology delineate mechanisms to discover new drug candidates. The successful candidate will have a broad understanding of biophysics biochemistry cell and molecular biology human genomics. This role will require working closely with a global discovery team to incorporate new technologies to facilitate the progression of novel clinical candidates that allow for maximal therapeutic impact and differentiation for patients. Primary responsibilities will be leading both internal as well as external laboratory-based activities to design and execute experimental studies generate data and report results to a broad program team. The candidate must have good organizational writing and communication abilities to communicate results and ideas with other team members including non-scientists.
DUTIES AND RESPONSIBILITIES
- Lead the implementation of experimental design assay development cell-line characterization and modification with novel scientific platform technologies and high translational relevance
- Perform in vitro or ex vivo cell-based studies to characterize disease biology
- Conduct lead identification and drug candidate profiling and characterization
- Enable the Brii discovery strategy by ensuring biological capabilities are aligned with new technologies and the broader scientific vision
- Develop evaluation plans to assess platform technologies and new drug modality areas of interest
- Communicate with scientific and executive leaders
- Design and execute experimental studies and ensure all data and results are carefully documented in Brii electronic lab notebook systems.
- Collaborate coordinate and lead external CRO teams
- Contribute to the preparation of scientific reports for project teams
- Prepare review and deliver scientific presentations for internal/external use.
- Represent platform technologies on cross-functional teams
- Maintain knowledge of state-of-the-art principles and theories and apply to the design execution and interpretation of experiments.
- Work cross-functionally in complex and fast-paced research organization
- Represent Brii Bio externally at scientific meetings and through high impact scientific communications
QUALIFICATIONS
- PhD or equivalent in biochemistry cell biology molecular biology immunology or a related discipline with 4 years of post-PhD experience preferably in industry.
- In-depth knowledge with hands-on experience (preferred) in several key areas including biochemistry molecular biology cell biology and immunology.
- Understanding of advancing platform technology areas including CRISPR/Cas9 gene editing RNAi siRNA antisense oligos vector delivery methods antibody drug conjugates mRNA vaccine and bioinformaticssystems.
- Experience leading drug discovery program biology as part of a larger research team.
- Line management of 13-person research team.
- Demonstrated ability to work independently and collaborate in a team-oriented environment
- Solid track record of completing challenging technical problems independently and creatively exemplified by publication of research in high-quality scientific journals.
- Strong written verbal and interpersonal communications skills and ability to work efficiently and productively in a dynamic scientifically rigorous and fast-paced environment.
The above is intended to describe the general content of and requirements for the performance of this job. It is not to be construed as an exhaustive statement of duties responsibilities or physical requirements. Nothing in this job description restricts managements right to assign or reassign duties and responsibilities to this job at any time. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Brii Biosciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity or expression pregnancy age national origin disability status genetic information protected veteran status or any other characteristic protected by law. We value diversity and are committed to creating an inclusive environment for team members from all backgrounds.
Required Experience:
Staff IC
Employment Type
Full-Time
