Senior Manager NGS Bioinformatics
Senior Manager NGS Bioinformatics
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$ 115398 - 167845
1 Vacancy
Job Description
Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
The OpportunityI. Leadership and Management:
Lead and manage a team of bioinformaticians providing mentorship and guidance. Works with senior leadership to establish goals and objectives including the definition of work products and timelines. May also participate in developing strategy and setting overall direction. Develop and implement strategic plans for the bioinformatics team. Ensure timely delivery of bioinformatics analyses and reports. Foster a collaborative and innovative team environment. Attracts retains and develops high quality staff. Establishes and maintains a work environment conducive to high performance. Addresses the training and professional development needs of the staff.
II. Project Management:
Oversee the bioinformatics aspects of NGS projects from inception to completion. Coordinate with project managers laboratory scientists and other stakeholders. Ensure projects are delivered on time within scope and within budget.
III. Bioinformatics Analysis:
Develop and implement bioinformatics pipelines and workflows and tools for NGS data analysis. Perform data quality control alignment variant calling and annotation. Interpret and present results to scientific and non-scientific audiences. Design and apply novel computational methods/bioinformatics algorithms to aid in the analysis and interpretation of genetic data Analyze large molecular datasets of tumor sequencing data to help critically review and analyze the results of specimen testing working closely with faculty and staff to troubleshoot problems recommend technology-based solutions or determine computational strategies. Develop and validate new data analysis software tools to enhance ability of faculty to interpret genetic data output.
IV. Research and Development:
Stay up-to-date with the latest advancements in NGS technologies and bioinformatics methods. Identify and integrate new tools and technologies to improve data analysis capabilities. Lead research initiatives to develop novel bioinformatics approaches.
V. Collaboration and Communication:
Work closely with cross-functional teams including molecular scientists geneticists clinicians pathologists oncologists and other clinical healthcare professionals. Communicate complex bioinformatics concepts and results to stakeholders. Prepare and present technical reports to all cross functional teams
VI. Regulatory Compliance:
Ensure all bioinformatics analyses and reporting comply with relevant regulatory standards (e.g. CLIA CAP FDA). Develop and maintain documentation and standard operating procedures (SOPs) for clinical bioinformatics processes. Participate in audits and inspections to ensure regulatory compliance. Performs all other duties as assigned.
Qualifications
Qualifications
Ph.D. in Bioinformatics Computational Biology Genomics or a related field.
Minimum of 8 years of experience in bioinformatics with a focus on NGS.
Proven experience in managing and leading bioinformatics teams.
Strong expertise in NGS data analysis including experience with various sequencing technologies (e.g. Illumina PacBio Oxford Nanopore).
Proficiency in programming languages such as Python R and Perl.
Experience with bioinformatics tools and databases (e.g. GATK SAMtools BWA Ensembl COSMIC).
Knowledge of regulatory requirements for clinical genomics (e.g. CLIA CAP FDA).
Excellent problem-solving skills and attention to detail.
Strong communication and interpersonal skills. Skills Abilities and Competencies
Experience in oncology or precision medicine.
Familiarity with electronic health record (EHR) systems and clinical data integration.
Knowledge of cloud computing and high-performance computingenvironments.
Scripting using Python or Perl.
Prior experience developing software in a CLIA regulated environment is preferred.
SQL proficiency using MySQL and/or SqlServer knowledge of NoSQL and other DBMS ( MongoDB Apache CouchDB) a plus
Familiarity with data engineering and workflow management platforms (e.g. AirflowArgo)
Ability to work with and manage large and heterogenous data sets
Excellent skills for working with the Linux operating system and high-performance computing clusters (HPCC) including the LSF queueing system to undertake genomic analyses from assembly of NGS reads through subsequent analyses
Strong interpersonal skills and ability to effectively interact with all levels of staff and external contacts.
Excellent communication and effective problem-solving skills; and ability to interact with multidisciplinary staff in a fast-paced environment. The successful candidate should be able to work independently prioritize and manage a variety of tasks and shift priorities rapidly.
Ability to work in a highly collaborative and intellectually challenging environment
Ability to rapidly assess learn and implement new technologies / services as new needs arise as well as communicating use of those technologies
Excellent attention to detail
Proven track record of developing high-quality computational methods and tools in form of scientific publications or through successful participation in hackathons challenges or open-source software projects
Additional Job Details (if applicable)
Remote Type
Work Location
Scheduled Weekly Hours
Employee Type
Work Shift
Pay Range
$115398.40 - $167845.60/AnnualGrade
8EEO Statement:
Mass General Brigham Competency Framework
At Mass General Brigham our competency framework defines what effective leadership looks like by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance make hiring decisions identify development needs mobilize employees across our system and establish a strong talent pipeline.
Required Experience:
Senior Manager
Employment Type
Full-Time
