Senior Scientist I (PK/PD Modeling)
Senior Scientist I (PK/PD Modeling)
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1 Vacancy
Job Description
The AbbVie portfolio consists of several marketed products in areas including eye care immunology oncology virology and womens health as well as a pipeline containing multiple promising new molecules being studied in hundreds of clinical trials or advancing from Discovery into Development. AbbVie is a global organization with US research sites in Boston (Cambridge and Worcester MA) Chicago (North Chicago IL) and the San Francisco Bay Area (South San Francisco CA). The biotherapeutics portfolio is comprised of diverse and tailored modalities including mono- and bispecific antibodies antibody-drug conjugates antibody fragments gene therapies and cell-based therapies.
The Quantitative Translational and ADME Sciences (QTAS) group is searching for a Senior Scientist to provide mechanistic and translational modeling and project support in all disease areas informing decision-making for primarily large but also small molecule projects from discovery through the early stages of clinical development. The candidate will establish innovative translational modeling approaches such as mechanistic PK/PD or systems modeling across disease and therapeutic areas as well as provide QTAS project support enabling translation of assets from Discovery into early Development. The position requires close collaboration with Discovery and Development project teams clinical pharmacology and other stakeholders to develop and execute QTAS and PK/PD strategies necessary to facilitate the advancement of our pipeline.
Key Responsibilities:
Develop and implement innovative quantitative analyses and strategies for translational modeling across Discovery and Development projects
Liaise with Discovery biology pharmacology toxicology biomarker QTAS and clinical scientists to generate data and knowledge supporting the generation and implementation of translational models
Establish and maintain effective collaborations with key peer andteam stakeholders within QTAS Discovery and Clinical to facilitate knowledge and data integration for target prioritization biomarker selection candidate selection guidance in (pre)clinical study design human dose prediction and calculation of therapeutic index
Effectively communicate on strategies related to drug metabolism and pharmacokinetics (DMPK) and translational modeling and simulation
Maintain awareness of emerging literature and science in computational approaches and applications
Qualifications :
Basic Qualifications:
Bachelors (B.S.) Masters (M.S.) or Doctorate (Ph.D.) in in chemical mechanical or biomedical engineering; applied mathematics; quantitative pharmaceutical sciences or a related field with at 10 years of experience and Bachelors Degree OR 8 years of experience and Masters Degree. or Ph.D. and no experience necessary.
Hands-on experience with relevant modeling software and programming languages including MATLAB/SimBiology R Python WinNonLin/Phoenix etc. is required
Understanding of small or large molecule drug modalities and relevant analytical methods for measuring drug and biomarker levels in preclinical and clinical study samples is highly desired
Passion for data analysis solving technical problems and applying new technologies to further scientific goals and answer key scientific questions enabling informed decision-making
Publication record demonstrating PK/PD or systems modeling examples is highly desired
Highly-motivated self-driven and results-oriented person with excellent communication and presentation skills capable of both leading and being lead
High degree of flexibility in adapting to different projects and personalities as well as excellent networking and relationship-building skills (both internal and external) required
Must have strong communication skills and the ability to effectively communicate with both internal and external stakeholders and to audiences of diverse backgrounds
Prior experience in an experimental in vitro or in vivo biology field is desired
Interest in developing skills to support projects as a QTAS project representative in future is highly desired
Preferred Qualifications:
Doctorate (Ph.D.) in chemical mechanical or biomedical engineering; applied mathematics; quantitative pharmaceutical sciences or a related field with 1-3 years of pharmaceutical industry experience
Key Leadership Competencies:
Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance
Learns fast and can change course quickly when necessary
Raises the bar and is never satisfied with the status quo
Creates a learning environment open to suggestions and experimentation for improvement
Embraces the ideas of others nurtures innovation and manages innovation to reality
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements understate or local law:
The compensation range described below is the range of possible base pay compensation that theCompany believes in good faith it will pay for this role at the time of this posting based on the job gradefor this position. Individual compensation paid within this range will depend on many factors includinggeographic location and we may ultimately pay more or less than the posted range. This range may bemodified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick)medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vestedand determinable. The amount and availability of any bonus commission incentive benefits or any otherform of compensation and benefits that are allocable to a particular employee remains in the Companyssole and absolute discretion unless and until paid and may be modified at the Companys sole andabsolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:
No
Employment Type :
Full-time
Employment Type
Full-time
