Help us create a brighter tomorrow with biology. Were looking for mission-driven talented and kind people to join our team.
The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to purify and characterize broad classes of therapeutic proteins. A successful candidate will bring an outcome-oriented skillset to recombinant protein purification and characterization. You will work collaboratively with our teams to produce and purify diverse proteins from cell culture processes and be comfortable conducting broad characterization of purified species.
Responsibilities
Develop and optimize protein purification schemes for broad classes of recombinant therapeutic proteins.
Develop optimize and validate assays for protein quality and purity assessments for broad classes of recombinant therapeutic proteins.
Plan and execute experimentation to understand protein quality through cell line upstream and downstream process development.
Execute summarize and interpret routine and complex therapeutic protein characterizations.
Qualify and validate assays upholding highly rigorous standards for execution and documentation.
Routinely operate maintain and troubleshoot analytical instrumentation (HPLCs FPLCs mass spectrometers).
Author review and implement methods protocols validations and standard operating procedures.
Ensure processes are followed in accordance with these standards.
About You
Hold a PhD in Analytical Chemistry Molecular Biology Biochemistry Pharmaceutical Sciences with at least 2 years of biologics industry experience. Candidates without a PhD but with similar industry experience are encouraged to apply.
Have illustrated experience in therapeutic protein therapeutic purification across multiple modalities and are familiar with common characterization approaches (eg. HPLC SDS Western Blotting CE BLI LC-MS).
You have illustrated the ability to develop and execute intact mass sequence confirmation and PTM analysis (e.g. glycosylation disulfide mapping) through mass spectrometry.
Experience in the development and execution of GLP compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.
Have hands-on experience operating LC-MS. Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus. Including familiarity with proteomic software.
Are highly motivated to deliver successful outcomes for internal and external clients.
Excited to work with internal and external clients to deliver project excellence.
Have strong communication skills and comfortable teaching and sharing knowledge at multiple levels of technical detail.
$130000 - $160000 a year
Diversity:We value diverse people perspectives and knowledge. To this end we aim to foster a sense of belonging that enables everyone to bring their whole authentic self to work everyday. We are committed to growing a diverse and inclusive team that encompasses all types of people. We believe this can only be achieved by acknowledging the ancestral historic and current systemic and communal inequities.
Location:The San Francisco Bay Area (Emeryville CA)
Benefits:Company-covered medical dental and vision insurance for employee and spouse generous equity package retirement plan with company contribution flexible PTO with healthy time off minimums career coaching and mental health support and plentiful snacks and free lunch every day!
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