Lead or Senior Researcher - Babu Lab
Lead or Senior Researcher - Babu Lab
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$ 60320 - 105040
1 Vacancy
Job Description
Overview
As a part of the Center of Excellence for Data-Driven Discovery in the Department of Structural Biology at St. Jude Childrens Research Hospital the Babu Group seeks a highly driven full-time experimental Senior or Lead Researcher with a strong background in molecular biology and mammalian cell culture techniques to support the G Protein Coupled Receptor (GPCR) Collaborative. The GPCR Collaborative is a recently established St Jude-funded national collaborative between six leading GPCR biology and pharmacology experts to reveal the molecular determinants and fidelity of GPCR signaling in health and disease. The goal of the Collaborative is to gain fundamentally new insights into GPCR physiology using state-of-the-art technologies that shift focus from time-averaged ensemble investigations towards understanding the properties and functions of single molecules and assemblies in space and time. This goal will be accomplished by leveraging the different expertise of the Collaborative members:
M. Madan Babu Member Dept. of Structural Biology St. Jude Childrens Research Hospital
Scott Blanchard Member Dept. of Structural Biology St. Jude Childrens Research Hospital
Robert Lefkowitz Chancellors Distinguished Professor of Medicine Duke University
Georgios Skiniotis Professor of Molecular and Cellular Physiology Stanford University
Alice Ting Professor of Genetics Biology and Chemistry Stanford University
The Babu Group uses data-driven approaches to understand sequence-function relationships in intrinsically disordered proteins and structure-function relationships in medicinally important structured protein families such as GPCRs and Kinases respectively. The Researcher/Senior Researcher will design and carry out experiments aimed at understanding mechanisms of G protein-coupled receptor (GPCR) signaling in human physiology and disease to develop novel therapeutic strategies. Work from our group has revealed insights into signaling mechanisms linking the ligand-binding pocket in receptors (Nature 2013) to activation-dependent conformational changes (Nature 2016) the selective binding of G proteins (Nature 2017) and the allosteric activation mechanism of G proteins (Nature 2015). We have demonstrated that GPCR isoforms diversify signaling responses in different human tissues (Nature 2020) and that GPCRs are highly variable in the human population contributing to variable drug responses and posing an economic burden on healthcare systems (Cell 2018).
The successful candidate will be a fast learner who can operate independently with care and confidence to support day-to-day experimental efforts in the Group. They will provide research support perform experiments with guidance and oversee supply inventorying ordering and receiving. Successful candidates will have experience making media preparations performing standard molecular cloning procedures and handling mammalian cell lines. Excellent organization and communication skills are required to document experimental observations present results and coordinate materials for multiple experimentalists in the group. A large component of the weekly responsibilities will be 1) maintaining mammalian cell culture lines to support high-throughput assays to interrogate GPCR signaling and 2) maintaining ordering and organizing laboratory equipment and supplies. In this position the candidate will gain extensive experience in cutting-edge techniques to interrogate the biology structure and pharmacology of GPCRs the single most medicinally important protein family.
Responsibilities
- Maintaining mammalian cell culture lines and preparing lines for testing and various experiments under the supervision of senior Scientists
- Maintaining ordering and organizing laboratory supplies under the supervision of the Director of Laboratory Research
- Molecular cloning of single constructs and DNA libraries using modern assembly techniques
- Operating and maintaining laboratory equipment
- Meticulous electronic documentation of experimental observations procedures sample organization and results
Opportunities for Professional Growth
- The candidate will learn to analyze cellular phenotypes using fluorescence microscopy and flow cytometric analysis
- The candidate will learn how to genetically engineer mammalian cell lines
- The candidate will learn to use fluorescence- and luminescence-based biosensor and reporter assays to interrogate GPCR signaling
St. Jude Childrens Research Hospital is consistently named as one of Fortune magazine and Best Places to Work as well as Best Workplace for Women and Best Workplace for Diversity. We are in the heart of Memphis Tennessee a vibrant and friendly city at the historic American crossroads of music trade food and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Low cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude salaries are highly competitive.
St Jude Employees receive:
- Excellent healthcare plans with zero to low health premium costs
- Onsite health clinic pharmacy and exercise facilities
- Paid parental leave and adoption assistance
- Immigration Services
- Tuition Reimbursement
The Babu Group strives to build and maintain a culture of respect diversity and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.
Minimum Education and/or Training for Either level:
- Bachelors degree in a relevant scientific area is required.
Minimum Experience for Senior Researcher:
- 2 years of research experience is required with a Bachelors degree.
- No prior experience required with a Masters degree.
Minimum Experience for Lead Researcher:
- 5 years of research experience is required with a Bachelors degree.
- 3 years of experience is required with a Masters degree.
- No prior experience required with a PhD.
Salary Expectations:
A reasonable estimate of the current salary range is $54038 - $89148 per year for the role of Senior Researcher.
A reasonable estimate of the current salary range is $60320 - $105040 per year for the role of Lead Researcher.
Compensation
In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $60320 - $105040 per year for the role of Lead or Senior Researcher - Babu Lab.Explore our exceptional benefits!
No Search Firms
St. Jude Childrens Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
Required Experience:
Senior IC
Employment Type
Full-Time
