UNIV - Research Specialist III - Department of Medicine: Division of Cardiology

Job Description Summary

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Job Description

Job Duties:

30% - Conducting daily experiments to identify cellular and molecular mechanisms using animal and cellular models of disease. Develop primary cell culture models from human and mouse tissues to evaluate effects of inflammatory stimuli on cellular gene expression proliferation and signaling pathways. Expertise in cell biology sterile cell culture assay development qPCR western blot enzyme activity assays ELISA immunohistochemistry and microscopy is required. Additional biochemical molecular and cellular biology techniques such as working with co-cultures or 3D cultures and single-cell RNA sequencing are a plus.

30% - Performing animal behavioral and functional assessments to determine physiological impacts of disease and novel therapies. While expertise in murine behavioral echocardiography and telemetry are not required the candidate must be willing to acquire these skills.

15% - Supervise and assist lab trainees including graduate students rotation students and junior technicians in both laboratory practices and experimental skills.

15% - Manage and maintain wild-type and transgenic mouse colonies including breeding genotyping census and filing IACUC documents.

10% - Supervise and maintain laboratory safety and compliance criteria for working with primary human cells eye wash stations animal carcasses and other biohazards. Responsible for maintaining general lab cleanliness operation and ordering laboratory chemicals and other supplies. Assisting with general laboratory administrative tasks to ensure that projects are completed on time and within budget including laboratory maintenance resource organization ordering of supplies management of laboratory protocols and reports and coordination with collaborators.

Preferred Qualifications: Experience with single nucleus RNAsequecing experience with proteomics and metabolomics analysis first-author peer-reviewed publications.

Additional Job Description

Minimum Requirements: A bachelors degree in chemistry biology or other natural life or health care science directly related to the assigned area of research and two years advanced journel-level work experience in a clinical or research setting.

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Frequent) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb using step stool. (Infrequent) Ability to work in temperature extremes (32 F to 100 F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent) Ability to work in confined/cramped spaces. (Continuous) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent) Ability to fully use both legs. (Frequent) Ability to reach in all directions stretch bend while moving items/materials from both sitting and standing positions. (Frequent) Ability to maintain good olfactory sensory function/distinction. (Continuous) Ability to lift materials up to 20 lbs. unassisted. (Infrequent) Ability to lift and carry 4 liter waste material bottles a distance of 30 feet unassisted. (Frequent) Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet unassisted. (Infrequent) Ability to lift file boxes from floor level to counter tops unassisted. (Frequent) Ability to push/ Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches then down 20 inches into centrifuge drum unassisted. (Infrequent) Ability to lift 25 lbs. boxes from floor level to maximum height of 72 inches unassisted. (Infrequent) Ability to push/pull file boxes from one location to another at floor level. (Frequent) Ability to maneuver heavy equipment on bench tops 50 lbs. or greater unassisted. (Frequent) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to maintain 20/40 vision corrected in one eye or with both eyes. (Continuous) Ability to match or discriminate between colors normally. (Continuous) Ability to hear and recognize various alarms emitting from work area systems. (Continuous) Ability to hear and/or understand conversations. (Continuous) Ability to work in a darkroom for processing film etc. (Continuous) Ability to be qualified physically for respirator use initially and annually. (Continuous)

Additional New Requirements: Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes tools and equipment as required.

If you like working with energetic enthusiastic individuals you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race color religion or belief age sex national origin gender identity sexual orientation disability protected veteran status family or parental status or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications merit and business need.

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