Postdoctoral Fellow / PhD Candidate in Epigenetics and Musculoskeletal Biology (Research Institute)
Postdoctoral Fellow / PhD Candidate in Epigenetics and Musculoskeletal Biology (Research Institute)
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Job Description
Do you want to work for a world-renowned research institute that pushes the boundaries of biomedical science and health research Right here in Montreal! At the Research Institute of the McGill University Health Centre (RI-MUHC) you can be part of an organization focused on scientific discovery and innovation in patient-centered medicine. Join us today and make a difference!
Job Description
RESEARCH INSTITUTE OF THE MUHC
The Research Institute of the McGill University Health Centre (RI-MUHC) is a world-renowned biomedical and hospital research centre. Located in Montreal Quebec the Institute is the research arm of the McGill University Health Centre (MUHC) affiliated with the Faculty of Medicine at McGill University. The RI-MUHC is supported in part by the Fonds de recherche du Qubec - Sant (FRQS).
Introduction
Department / Research Program: Surgery / Surgical and Interventional Sciences (SIS)
The Research Institute of the McGill University Health Centre (RI-MUHC) is a world-renowned biomedical and hospital research centre. Located in Montreal Quebec it is affiliated with the Faculty of Medicine at McGill University.
We are inviting applications for a PhD position in Cell Molecular and Epigenetic Biology within the Orthopaedic Research Laboratory at the Shriners Hospital under the supervision of Dr. Lisbet Haglund. The successful candidate will join an interdisciplinary research project investigating epigenetic dysregulation in Adolescent Idiopathic Scoliosis (AIS) using patient-derived musculoskeletal cells and integrated clinical datasets.
Responsabilities and Objectives
Perform tissue-specific DNA methylation and gene expression analyses (e.g. bisulfite sequencing qPCR RNA-seq) on AIS patient samples
Culture and characterize primary chondrocytes osteoblasts and myoblasts derived from AIS and control tissues
Investigate epigenetic regulation of FGFR2 TNF NF-B and other identified targets
Analyze and interpret multi-omics data sets including transcriptomics and epigenomics
Apply epigenetic-modifying compounds (e.g. DNMT and HDAC inhibitors) to patient-derived cells and assess phenotypic rescue
Correlate molecular findings with clinical spinal parameters using imaging and modeling data
Contribute to manuscript preparation and present findings at national and international conferences
Collaborate with a multidisciplinary team of orthopaedic surgeons molecular biologists and imaging specialist.
Website of the organization
Required Skills
Excellent command of English (written and spoken)
Experience with primary cell culture RNA/DNA isolation qPCR and immunofluorescence
Familiarity with epigenetic techniques (e.g. DNA methylation assays chromatin modification studies) is an asset
Working knowledge of transcriptomic or epigenomic data analysis pipelines
Interest or experience in musculoskeletal biology scoliosis research or developmental disorders
Strong organizational and time management skills with the ability to work independently and as part of a team.
Additional information
Status: Temporary full time
Compensation Level: Commensurate with graduate funding policies and experience.
Work Schedule: Monday to Friday 9:00am to 5:00pm
Site: MGH 1650 Cedar Ave.
***If you wish to include a cover letter please attach it with your resume in one PDF document. ***
A Postdoctoral fellow is a full-time student currently enrolled in a Canadian University program. The individual must have recently been awarded (within 5 years) a PhD or equivalent. The Postdoctoral fellow will receive a stipend or a bursary from a professors grant for research activities that will be performed on a full-time basis. All benefits are administered by the University under which they are registered.
learn more about our benefits please visit IS NOT A HOSPITAL POSITION.
Equal Opportunity Employment Program
The Research Institute of the McGill University Health Centre hires on the basis of merit and is strongly committed to equity diversity and inclusion within its community. We welcome applications from all qualified candidates who self-identify as members of racialized groups/visible minorities women Indigenous persons persons with disabilities ethnic minorities and 2SLGBTQIA persons. We also welcome candidates with the skills and knowledge to productively engage with diverse communities. Persons with disabilities who anticipate needing accommodations for any part of the application process may confidentially contact
Employment Type
Full-Time
