Research Lab Operations Manager - Center for Genomic Medicine

Site: The General Hospital Corporation

Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

The Musolino and Lindsay laboratories are a team of clinicians and scientist working to understand the genetics of brain and systemic vascular disease and develop novel therpaies. As translational laboratories we levereage disease expertise state of the art molecular imaging and gene-editing technologies to understand how single gene mutations alter vessels in order to find better therapies and improve the quality of life of patients suffering monogenic vascular disorders.

The Research Laboratory Operations Manager will work in collaboration with the principal investigators center leaders and other personnel to support laboratory operations. This position is a combination of experimental and admistrative duties that oversees the daily operations of the research laboratory including maintaining equipment inventory protocols research inventories daily budget admistrative grant documetns and related inquiries. The incumbent will also provide functional guidance to and train lab personnel. Will perform hands on experiments including conduct routine molecular biology techniques (e.g. PCR recombinant DNA cloning DNA sequencing) and advanced imaging with an emphasis on microscopy. Will manage mammalian cell culture including iPSC-derived cells and assist with animal husbandry.

Will apply experience in molecular biology microscopy and mammalian cell culture as well as contribute murine experience. Additionally experience in induced pluripotent stem cell (iPSC) work is valuable along with interest in innovative delivery and genome engineering technologies. Contribute administrative experience in managing budgets timelines protocols and grant submission files.

• Oversees and manages day-to-day laboratory operations as well as technical and research support activities conducted in the laboratory collaborating with the principal investigators and others.
  • Contributes to planning and reviewing the areas performance; resolves problems and issues as they arise.
  • Coordinates and prioritizes research projects and experiments ensuring all activities are in line to meet research standards and goals.
  • Ensures detailed documentation of experimental protocols procedures and outcomes in an electronic lab notebook maintaining regulatory compliance and quality control standards.
  • Troubleshoots and resolves technical issues related to laboratory equipment and experiments.
  • Ensures all experiments and research projects as well as the laboratory are in compliance with regularoty requirements safety regulations; conduct regular audits and inspections to ensure compliance with regulatory standards; monitor and enforce laboratory safety protocols and procedures.
  • Develops and manages lab-wide data storage solutions to ensure secure organized access to research data for current and future studies.
• Carries out independent research projects which involve the execution of highly sophisticated techniques.

• Contributes to scientific literature and may present the results at hospital and outside meetings; may attend and/or present at scientific meetings and conferences.
• Provides administration of the lab in collaboration with the principal investigators center leaders and other staff.
  • Orients and trains new personnel in laboratory techniques mentors staff for ongoing development and promotes a culture of safety and excellence in lab procedures; serves as an ongoing resource to staff.
  • Participates in hiring performance evaluation corrective action as needed.
  • Coordinates and oversees assignment and work of students in the lab.
  • Contributes to the financial management of the lab including preparation of budgets overseering the use of laboratory funds and supply inventory; analyzes trends and produces reports; processes reimbursements.
  • Assists in preparing grant submissions and proposals including writing and review.
  • Manages administrative documents overseeing data collection and storage and maintaining data management systems.
  • Manages lab space and equipment including troubleshooting service agreements and vendor relationships.
  • Prepares maintains and communicates documentation and manuals to support technical and operational needs; participates in the development and updating of lab policies.
  • Attends and/or leads lab and departmental meetings.
• Represents the lab on department and hospital committees as needed.
• Performs other responsibilities and participates in meetings workgroups and projects as assigned.

Bachelors degree required in directly related scientific field. MS preferred.

7 years of progressively more responsible research laboratory experience as well as 1 one of management experience including operational financial and staff oversight.

Technical experience must include performing molecular biology techniques (e.g. bacterial culture molecular cloning human cell culture DNA sequencing etc.).

• Advanced knowledge of research laboratory techniques experimental processes and equipment.
• High level of technical knowledge skill and ability to execute research experiments and projects in an effective and timely manner.
• Advanced knowledge of lab safety and regulatory operations with the ability to ensure this knowledge is put into practice across the lab.
• Demonstrated ability to coordinate and manage activities within a laboratory setting.
• Ablity to work in a highly collaborative environment as a member of a team and independently.
• Ability to make independent effective decisions.
• Excellent judgment and ability to interpret information and protocol requirements.
• Aptitude for technical problem-solving.
• Strong communication skills to effectively document technical information and inform and discuss on technical financial and administrative matters.
• Ability to effectively supervise the work of others.
• Excellent organizational skills to formulate and complete vigorous timetables and meet the grants complex financial restrictions.
• Knowledge of NIH awards and funding regulations.
• Must possess strong budget management skills.
• Understanding of and skill with databases and computer applications used in a research and administrative setting.

Duties will be performed in a research laboratory with typical conditions and may include chemicals and requirements may include periods of prolonged sitting and standing. Work may include non-standard work hours to accommodate research meetings training or other to meetings and conferences may occur.

Daily functional oversight of a team of research technical staff as well as functional guidance and administrative management for research fellows.

Financial management of lab in conjunction with PI and grants administrators with a budget over $5 million.

Onsite

185 Cambridge Street

40

Regular

Day (United States of America)

The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religious creed national origin sex age gender identity disability sexual orientation military service genetic information and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact Human Resources at .

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