Senior Director, Translational Research Haematology R&D
Senior Director, Translational Research Haematology R&D
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Job Description
AstraZeneca is a global science-led patient-focused biopharmaceutical company that emphasizes the discovery development and commercialization of prescription medicines for some of the worlds most serious diseases. We are more than just a leading pharmaceutical company; we cultivate an environment that fosters collaboration and innovation by attracting top talent and nurturing development.
Within Haematology R&D we are dedicated to advancing science to deliver life-changing medicines to patients in need. Our combination-focused pipeline harnesses the power of multiple scientific platformsimmuno-oncology tumor drivers and resistance DNA damage response antibody-drug conjugates cell therapy and epigeneticsto address unmet needs in hematological cancers. Our commitment to scientific discovery and collaboration drives our mission to eliminate cancer as a cause of death managing the value chain from discovery to late-stage development.
Translational Medicine (TM) transforms hematological cancer biology into actionable insights for therapeutic development and clinical decision-making within the Oncology space. Operating within the Haematology R&D division TM is responsible for delivering innovative strategic biomarker studies to support Hematology & Oncology project teams to make decisions. The TM team collaborates closely with preclinical bioscience and discovery early clinical development and precision medicine & biosamples functions. TM provides robust scientifically-driven biomarkers for all Haematology projects covering leukemia lymphoma and myeloma. This includes assay development technical validation and biomarker analysis for clinical samples. TM conducts translational research across early and late-phase clinical engagements integrating advanced biomarker strategies to enhance therapeutic outcomes. The Translational Research(TR) group is responsible for delivering laboratory assay development across our drug programs and impactful translational insights across our high priority cancer types.
Key Responsibilities and Accountabilities
The Sr. Director Translational Research plays an integral role in the development and execution of critical projects that support the Haematology Translational Medicine Departments aims in Translational Medicine clinical trial support and drug development. The Sr. Director Translational Research will more specifically in this role:
- Lead the development of scientifically rigorous preclinical and clinical translational research assays to assess pharmacodynamic changes mechanisms of action and resistance establish early signs of efficacy and drive patient selection and combination strategies across the Hematology portfolio.
- Design and execute strategies to understand haematological tumor biology that supports the AZ portfolio. This work includes but is not limited to target expression post-therapy new MRD technology and platforms back-translating resistance mechanisms and informing new combinations across hematology indications.
- Manage a team of lab-based Translational Research Scientists to support Hematology Translational Medicine research efforts.
- Integrate Translational Medicine Research Scientists with broader drug development teams including translational medicine (TM leads data scientists etc.) discovery and clinical groups.
- Engage with internal and external experts to advance the portfolio and establish partnerships with academic collaborators.
- Present and communicate research findings to internal and external collaborators including upper management and regulatory agencies and at scientific conferences.
- Demonstrate excellent organizational and communication skills for cross-functional interactions.
- Perform all duties in compliance with internal SOPs and external regulations.
Minimum Qualifications:
- Advanced degree (e.g. PhD MD MD/PhD) with a focus on cancer biology immunology and/or multi-omics with experience in haematology-oncology highly desirable.
- Minimum of 10 years experience in oncology translational research particularly in drug discovery and development.
- Proven excellence in designing executing and interpreting cancer biomarker studies in preclinical models and clinical trials including biomarker development validation and clinical application.
- Experience managing a team of scientists and delivering high-quality science impacting decision-making.
- Familiarity with novel technologies applicable to cancer biomarker and/or immune response analysis (e.g. next-generation omics immunohistochemistry flow cytometry).
- Experience with multiple modalities such as small molecules antibody-drug conjugates Tcell engagers CAR-Ts and epigenetics agents.
- Knowledge of clinical protocol design trial operations biospecimen logistics and biomarker assay validation.
- Proven ability to develop collaborative partnerships that drive sustainable business results.
- Strong interpersonal skills team collaboration and aptitude in training and supervising direct reports.
- Excellent written and oral communication skills.
- Robust track record of scientific achievement as evidenced by publication record.
Working at AstraZeneca
Here youll have the chance to create a substantial difference to patients lives! With science at its heart this is the place where breakthroughs born in the lab become transformative medicines for the worlds most complex diseases. Answer unmet medical needs by pioneering the next wave of science focusing on outcomes and crafting the patient ecosystem.
Our Waltham Massachusetts facility develops life changing small-molecule research in North America with innovative laboratories at the Gatehouse Park Bio Hub just west of the city center. Our BioHub facility is a bold new R&D initiative which fosters life science discoveries and the exchange of ideas. Here we play host to some of the most cutting-edge technology and lab spaces all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station the location provides you the ability to work in the heart of one of the worlds most vibrant research centers.
Our Waltham site offers a variety of amenities help keep our employees happy and engaged. This includes a fitness center employee healthcare clinic electric vehicle charging stations full-service cafeteria and copy center. This is where youll find newly-designed activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.
As AstraZeneca continues to put patients at the forefront of our mission we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here:Kendall Square Press Release
When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
Next Steps Apply now!
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds with as wide a range of perspectives as possible and harnessing industry-leading skills. We believe that the more inclusive we are the better our work will be. We welcome and consider applications to join our team from all qualified candidates regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment) as well as work authorization and employment eligibility verification requirements.
Date Posted
05-Jun-2025Closing Date
29-Jun-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Exec
Employment Type
Full-Time
