Expert II Data Science, Cargo Design

Job Description Summary

This position will be located at the San Diego site and will not have the ability to be located remotely. Please note that this role would not provide relocation and only local candidates will be considered.
Internal Title: Expert II Data Science
We are recruiting a highly motivated and innovative Bioinformatics/Data Scientist to join our multidisciplinary team advancing next-generation gene therapy programs. This role offers a unique opportunity to drive the design optimization and evaluation of gene therapy payloads working at the intersection of computational biology high-throughput experimentation and therapeutic discovery. The successful candidate will contribute to projects that integrate cutting-edge bioinformatics machine learning and functional genomics to accelerate the development of transformative gene therapies.

Job Description

Key Responsibilities:

• Designing implementing and maintainingcustom computational pipelinesfor analysis of bulk and single-cell sequencing data includingbut not limited to RNA-Seq smRNA-seq scRNA-seq and scATAC-seq.
• Applyingmachine learning statistical modeling and data integrationapproaches to guide large-scale functional screens with the goal of identifying and optimizing functional elements for gene therapy payloads.
• Developingscalable reproducible and well-documented pipelinesfor quality control processing and integrative analysisof diverse high-throughput sequencing datasets.
• Integratingpublicly available and internal datasetsto uncover actionable biological insights that inform payload design.
• Staying current with emerging technologies and advances inbioinformatics gene therapy and synthetic biology and proactively propose innovative approaches to improve experimental design and analysis.
• Presenting results methodologies and key insights to multidisciplinary teams and stakeholders throughclear visualizations written reports and scientific presentations.

Essential Requirements:

• Educational Background: Ph.D Bioinformatics Computational Biology Computer Science (recent Ph.D. welcome to apply) MS degree in bioinformatics computational biology computer science structural biology or a related field with 4 years of relevant industry research experience
• Proficiency in developing and deployingNGS data analysis pipelines with expertise in Python R and workflow management tools.
• Hands-on experience withsingle-cell data analysisand familiarity with key tools and algorithms in the field.
• Strong track record of applyingmachine learningto genomics problems supported bypeer-reviewed publications.
• Excellent interpersonal and written communication skills; capable of effectively engaging with collaborators across scientific and technical disciplines.
• Independent and critical thinker with strongproblem-solving skills a collaborative mindset and the ability to thrive in a dynamic team environment.

Desired Requirements

• Solid understanding ofgene therapy principles including AAV vector engineering promoter/enhancer function and payload design considerations.

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between: $103600 and $192400/year; however while salary ranges are effective from 1/1/25 through 12/31/25 fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further final pay determinations will depend on various factors including but not limited to geographical location experience level knowledge skills and abilities. The total compensation package for this position may also include other elements including a sign-on bonus restricted stock units and discretionary awards in addition to a full range of medical financial and/or other benefits (including 401(k) eligibility and various paid time off benefits such as vacation sick time and parental leave) dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an at-will position and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment hiring training promotion or other employment practices for reasons of race color religion sex national origin age sexual orientation gender identity or expression marital or veteran status disability or any other legally protected status.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the application process or to perform the essential functions of a position please send an e-mail to or call 1 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

$103600.00 - $192400.00

Skills Desired

Biostatistics Computer Programming Data Analysis Databases Data Management Data Mining Data Quality Data Visualization Deep Learning Graph Algorithms High-Performance Computing Logistic Regression Model Machine Learning (Ml) Master Data Management Pandas (Python) Python (Programming Language) R (Programming Language) Random Forest Algorithm Sql (Structured Query Language) Statistical Modeling Time Series Analysis