Associate Director Integrated Bioanalysis, Quantitative Mass Spectrometry
Associate Director Integrated Bioanalysis, Quantitative Mass Spectrometry
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Job Description
Would you like to be part of a team that is at the leading edge of bioanalysis and omics technologies Do you aspire to work in a world-leading innovative and cross-functional environment Are you looking to join a company that follows the science and turns ideas into life changing medicines Then AstraZeneca might be the one for you!
We are seeking for a motivated and passionate individual to join us as an Associate Director EUDiscovery Bioanalysis Quantitative Mass Spectrometry in our Integrated Bioanalysis (IBA) organization within Clinical Pharmacology and safety sciences (CPSS). Leading a European-based team by example you will support ADC and biopharmaceutical drugdiscovery and development Multi-omic studies as well as biomarker assessments for critical projects within the AstraZeneca portfolio employing mass spectrometry-based approaches.
You will work at the forefront of bioanalytical sciences and play a key role in the development and progression of new medicines to the market. We are looking for an enthusiastic and innovative team player with experience of line management and detailed knowledge of Bioanalysis LC-MS workflows and demonstrated hands-on experience. You will need to use your experience and consistent track record to design develop and deliver robust bioanalytical strategies and associated bioanalytical methods; you will need to ensure that assays are shown to be fit-for-intended purpose and provide data that will allow project teams to make informed decisions with confidence. As a Subject Matter Expert you will be responsible for enhancing the iBA reputation for scientific excellence by presenting at internal and external meetings and publishing manuscripts. You will be expected to represent the department on multidiscipline cross functional drug development teams and work alongside colleagues & stakeholders across iBA and CPSS functions and partner organisations.
The position will be based at our vibrant strategic R&D site in Gothenburg Sweden.
What you will do
As an Associate Director Integrated Bioanalysis Quantitative Mass Spectrometry in IBA at AstraZeneca your main accountabilities will be to:
Lead a team of bioanalytical and mass spectrometry experts based in the UK and Sweden in non-GXP bioanalysis of large molecules
Develop novel quantitative mass spectrometry workflows combining digestion-based or intact molecule analysis to address sophisticated bioanalytical challenges related to drug discovery and development for ADC oligonucleotide and other drug modalities in a variety of biological matrices.
Elaborate validate/qualify state-of-the-art mass spectrometry assays in support of pharmacokinetic toxicokinetic pharmacodynamic mechanistic safety prognostic and diagnostic biomarkers
Lead internal/external collaborative projects working together with safety scientist pharmacologists toxicologists imaging scientists pathologists data scientists and translational science experts across global AstraZeneca teams
Support effective project planning and project management from sample arrival through to assisting with reports to collaborators.
Operate maintain and troubleshoot a variety of recent instruments
Serve as functional representative/expert on multidisciplinary project teams
Adhere to established Standard Operating Procedures industry practice and regulatory guidance as appropriate
Contribute to validation/qualification protocols and reports bioanalytical reports clinical study reports as appropriate
Requirements:
PhD in Analytical Chemistry Biochemistry or related field with a strong expertise in mass spectrometry for bioanalysis and antibody drug conjugates.
Innovative and influential bioanalytical leader capable of defining leading and implementing robust bioanalytical strategies risk mitigations and solutions to challenges in support of diverse project teams.
In depth knowledge of bioA/biomarker concepts such of context of use or fit for purpose assay validation/qualification.
5 years of relevant industry/biotech experience in mass spectrometry-based bioanalysis.
Experience of leading teams with proven ability to coach mentor and manage people to successfully deliver to projects.
Excellent skills in study design implementation of challenging and innovative LC-MS assays and data interpretation in the field of biomolecule characterization and/or multi-omics.
Hands-on experience in the operation of high resolution (qTOF IMS-TOF Orbitrap) and QqQ instruments and demonstrated experience with various acquisition modes (DDA DIA PRM MRM etc)
Proven track record of sample preparation and data acquisition method development and optimization.
Strong record of productivity and scientific publications.
Excellent organizational documentation and technical writing skills.
Excellent command of English (written and oral)
Strong communication and interpersonal skills.
Desirable:
Experience with a broad array of multiomics techniques including but not limited to proteomics metabolomics lipidomic RNAseq cell- painting or genomics applications.
Background in bioinformatics/statistical analysis.
Familiarity with biomarker discovery and validation and with drug metabolite identification and profiling studies.
Applied knowledge of bioanalytical techniques that would strengthen the departments bioA toolbox e.g. Flow Cytometry HPLC-MS/MS high sensitivity immunoassay platforms qRT-PCR dd-PCR.
Contributed to regulatory submission documentation such as INDs CTAs IBs ISI and/or NDAs/BLAs and experience in regulatory authority responses across multiple geographies.
Proven experience of operational streamlining and use of innovation tools such as AI within the workplace.
Why AstraZeneca
At AstraZeneca when we see an opportunity for change we seize it and make it happen because any opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial -finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means were opening new ways to work pioneering cutting edge methods and bringing unexpected teams together. Interested Come and join our journey.
So Whats Next
Are you already imagining yourself joining our team Good because we cant wait to hear from you. We welcome your application no later than June 3rd 2025.
Date Posted
21-May-2025Closing Date
03-Jun-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Director
Employment Type
Full-Time
