Postdoctoral Fellow â Immuno-Oncology Discovery
Postdoctoral Fellow â Immuno-Oncology Discovery
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Job Description
Postdoctoral Fellow ImmunoOncology Discovery
Location: Gaithersburg US
Department: Oncology
Our Postdoc Programme is for selfmotivated individuals looking to take on interesting high impact projects in a collaborative challenging and reputable environment.
Do you have expertise in immunology and passion for tumortargeting therapies Would you like to be part of a crossfunctional team that is driving the discovery of the nextgeneration of drugs for treating cancer At AstraZeneca we follow the science and turn ideas into lifechanging medicines. Apply today if you want to join the ImmunoOncology Discovery group within the Early Oncology department and unlock the power of what science can do!
Therapeutic Area Description:
At AstraZeneca we turn ideas into life changing medicines. Our goal in Early Oncology Discovery is to push the boundaries of science to change the practice of medicine transform the lives of patients living with cancer and ultimately eliminate cancer as a cause of death.
Academic Supervisor:
Remy Bosselut Senior Investigator National Cancer Institute NIH
Project Focus:
A major focus of our group is to understand the mechanisms by which T Cell Engagers can safely orchestrate antitumor response and to develop new therapeutic modalities to treat patients with cancer. Our postdoctoral fellow will build on the recently developed CD8selective T Cell Engager platform to dissect the biology underpinning the activity of these new drug modalities. In collaboration with experienced AZ scientists in bioscience and biologics engineering you will investigate how these new therapies are engaging the immune system and could be combined with other drugs to fight cancer. Ultimately this research will help to better understand how these new therapeutics work and will facilitate the development of the nextgeneration of immunooncology drugs.
Key Duties & Responsibilities:
This is a unique opportunity to build on our innovative immunooncology pipeline and provide critical insights into the novel biology behind the T Cell Engagers developed at AstraZeneca. This project will directly influence the evolution of our discovery platforms by tackling important questions related to the mechanism of action of these new drug modalities. You will be interacting with highly skilled experts from multiple disciplines and build both technical expertise and a scientific network. Together with the access to stateoftheart facilities and innovative drug platforms these resources will strongly facilitate the firstauthor publication in highquality journals. This is an exciting opportunity for an outstanding and ambitious biologist with experience in immunology or protein engineering to join the ImmunoOncology Discovery group within the Early Oncology department.
Develop in vitro assays and in vivo syngeneic models to investigate the contribution of T cell subsets to T Cell Engager function
Dissect the role of T Cell Engagers on immune cell function migration and maintenance in syngeneic animal models
Leverage core technology platforms (singlecell proteomic and genomics multifluorescence imaging spatial transcriptomics) to dissect immune responses in vivo
Collaborate with biologics engineers to design new T Cell Engagers and test new hypotheses
Plan write and publish highquality scientific papers and present at key conferences
Essential Qualifications / Education:
PhD in Biology or related field
A maximum of 4 years of postdoctoral experience.
Strong immunology and tumor biology experience
Proficient in animal model development
Expertise in assays and models to study T cell function in vivo
Extensive experience with multicolor flow cytometry to characterize T cell populations
Strong planning organizational and time management skills
Proven track record of publication in scientific journals and experience in oral presentations
Desirable Requirements:
Experience with cell culture and functional in vitro assays
Familiar with antibody structure and protein engineering strategies is a plus
Understanding of highdimensional analyses (flow cytometric or genomic) is preferred
Experience with spatial analyses (multifluorescent imaging or spatial transcriptomics) is an advantage
Selfdriven resultsoriented and highly motivated individual
Ability to independently design research plans and critically analyse experimental results
Strong interpersonal and collaboration skills
Length of Program guide: This opportunity is tailored for PhDqualified students aiming to undertake research within the industry potentially lasting up to three years. It is ideal for those looking to advance their careers while preserving strong connections to academia. Participants are encouraged to continue enhancing their scientific profiles through publications and conference attendance.
AZs Postdoc Programme: at AstraZeneca: Open Date: Apr 21 2025
Req Close Date: May 25 2025
To find out more go to: and anticipate a high volume of applicants so do not delay applying today! Each applicant is individually assessed during our interview process which includes several stages. Please note that candidates may not be invited to participate in every stage depending on their fit and skills as evaluated at each step.
Salary for this role is based on years of experience after obtaining PhD is a minimum of US$99900 up to Max of US$107500 shortterm incentive. Some relocation supplements depend on distance and location at the employers discretion.
Date Posted
08May2025Closing Date
24May2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Employment Type
Full-Time
