Director, DMPK
Director, DMPK
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1 Vacancy
Job Description
About Us
Valo Health is a technology company that is integrating humancentric data and AIpowered technology to accelerate the creation of lifechanging drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive with a much higher probability of success. We are using models early to fail less often executing clinical trials to add valuation to the company and generating fitforpurpose data to feed back into Valos Opal Computational Platform as we reinvent drug discovery and development from the ground up. Disease doesnt wait so neither can we.
About the Role...
As Director DMPK you will provide scientific leadership and strategic guidance as a functional area representative in a core team of interdisciplinary functional leads and manage activities associated with design management analysis and interpretation of both in vitro and in vivo experiments of absorption distribution metabolism and elimination for Valos internal and partnered small molecule drug discovery programs. In this capacity you will coordinate and oversee activities supporting compound assessment and advancement ranging from hit identification to drug candidate development. In addition you will provide domain area expertise to crossfunctional company initiatives and novel innovations including development of advanced predictive ADME/PK modeling methodologies and technologies.
What Youll Do...
- Work closely with a team of experienced drug hunters to create novel differentiated drug candidates by providing strategic guidance and execution associated with in vitro and in vivo profiling IVIV correlation and extrapolation PK/PD/Effect relationship development and human dose projection to move programs from target concept to the clinic.
- Partner closely with a team of AI/ML and data scientists to develop and implement a comprehensive and robust platform for in silico prediction of complex PK/ADME properties.
- Identify qualify engage and manage external providers of in vitro ADME and in vivo PK services; analyze and interpret resulting data.
- Together with in vitro ADME leadership drive a crossfunctional strategy aimed at capability refinement and expansion to address growing portfolio needs.
What You Bring...
- Broad DMPK experience and expertise spanning target assessment to clinical development with an awareness of regulatory guidance and industry trends.
- Leadingedge mindset in relation to current experimental and computational DMPK approaches and techniques. Modeling and simulation expertise preferred.
- Track record of success rapidly identifying and advancing preclinical development candidates through appropriate stage gates enabling key go/no go decisions.
- Small molecule drug development experience across multiple indications. Experience in Cardiovascular Obesity and CNS indications as well as grounding across multiple modalities a plus.
- Ability to effectively communicate influence and lead in a matrix environment.
- Success at sourcing and managing CROs to perform both in vitro assays as well as in vivo studies to supply timely and impactful data to project teams.
- Ph.D. in a relevant scientific discipline and 10 years of drug discovery experience or BS/MS and 15 years.
More on Valo
Valo Health LLC (Valo) is a technology company built to transform the drug discovery and development process using humancentric data and artificial intelligencedriven computation. As a digitally native company Valo aims to fully integrate humancentric data across the entire drug development life cycle into a single unified architecture thereby accelerating the discovery and development of lifechanging drugs while simultaneously reducing costs time and failure rates. The companys Opal Computational Platform is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal oncology and neurodegenerative diseases. Founded by Flagship Pioneering and headquartered in Lexington MA. Valo also has offices in New York NY. To learn more visit .
Required Experience:
Director
Employment Type
Full Time
