Senior Scientist (Hematology Oncology)
Senior Scientist (Hematology Oncology)
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Job Description
Senior Scientist (Hematology Oncology)
Introduction to role:
We are seeking a highly motivated Senior Scientist in hematology oncology with a track record of scientific excellence to join our team in Waltham MA. As a Senior Scientist you will be leading from the bench and a member of the in vivo team focused on delivering in vivo pharmacology datasets that will have a direct impact on the drug discovery pipeline. Are you ready to make a difference in the fight against cancer
Accountabilities:
Use in vivo technical skills to support oncology drug discovery by:
Developing and working with various in vivo models of cancer including subcutaneous and disseminated cell line and patientderived xenograft models
Developing designing and executing tolerability PKPD and efficacy studies to build comprehensive in vivo pharmacology data packages to support drug discovery programs
Profiling tissue samples to explore mechanisms of drug response using both traditional and novel approaches
Work collaboratively across project teams and disciplines to advance projects
Work with various software programs and databases to capture all study data
Independently provide data analysis and interpretation
Present in relevant meetings to project teams and stakeholders Proactively and clearly communicate within the in vivo team and the broader AZ organization
Stay up to date with relevant scientific and technical expertise in cancer biology and pharmacology by actively reading the literature
Essential Skills/Experience:
PhD with >2 years or MS with >5 years of research experience in biology pharmacology or related field
Handson experience developing and working with hematological oncology in vivo models including xenografts (subcutaneous and disseminated models)
Ability to develop and deliver clear presentations and effectively communicate key messages
Ability to work both independently and within multidisciplinary project teams
Strong organizational and time management skills
Experience using molecular and cell biology techniques such as Western blot RTPCR flow cytometry and ELISA/MSD
Strong interpersonal skills with evidence of delivery in a teamoriented collaborative environment
Familiarity with software programs include GraphPad Prism Microsoft Office suite and in vivo data capture systems (e.g. Study Log or similar)
Desirable Skills/Experience:
Prior experience in biotech or pharma
Experience delivering all aspects of PKPD efficacy and tolerability studies in xenograft models
Expertise in multiple myeloma lymphoma and/or acute myeloid leukemia biology
Experience with flow cytometry including ability to design panels profile markers in tissue using MACSQuant and/or BD cytometers and analyze data in FlowJo
Experience with humanized xenograft models
Experience using small animal imaging modalities (e.g. Xenogen ultrasound)
Understanding of pharmacology concepts such as pharmacodynamics and pharmacokinetics
Experience in assay development for complex systems (ex. in vivo samples 3D cultures coculture etc.)
Join the team at the heart of AstraZeneca that is committed and encouraged to follow the science. Driven by our curiosity passion and determination we are paving the way to change the practice of medicine in Oncology. Ready to make a difference Apply today!
Date Posted
09May2025Closing Date
18May2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Senior IC
Employment Type
Full-Time
