Senior Scientist, PKPD
Senior Scientist, PKPD
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$ 152000 - 168000
1 Vacancy
Job Description
Description
Job Title:
Senior Scientist PKPD
Location:
San Diego CA / Hybrid / Remote
Position type:
FLSA:
Full time
Exempt
Department:
Finance ID:
Development Sciences
Profoundly Improve Peoples Lives by Revolutionizing the Delivery of RNA Therapeutics
At Avidity Biosciences we are passionate about the impact of every employee in realizing our vision of improving peoples lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed solutionoriented thinker join us in making a difference and become part of our growing culture that is integrated collaborative agile and focused on the needs of patients.
Avidity Biosciences Inc.s mission is to profoundly improve peoples lives by delivering a new class of RNA therapeutics Antibody Oligonucleotide Conjugates (AOCs). Utilizing its proprietary AOC platform Avidity demonstrated the firstever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1) Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered inSan Diego CA.For more information about our AOC platform clinical development pipeline and people please visit and engage with us on LinkedIn and X.
The Opportunity
We seek an experienced drug developer and scientist to join the Development Sciences team at Avidity Biosciences in La Jolla CA. This position will expand the PKPD and quantitative pharmacology efforts across all phases of development from research through approval. A highly visible role with the opportunity to define and implement quantitative modeling and simulation for a new class of Antibody Oligonucleotide (AOC) therapeutics. In addition the ideal candidate will work with the clinical teams as a clinical pharmacologist. Proven experience utilizing M&S approaches to solve drug development problems working on project teams and the ability to clearly communicate this work is required.
What You Will Contribute
- Interpret preclinical pharmacokinetic and pharmacodynamic data to inform the design of preclinical pharmacology and GLP toxicology studies
- Utilize existing and novel PKPD modeling and simulation approaches to answer complex biological and pharmacological questions regarding the mechanism of action of the AOC platform
- Independently conduct noncompartmental PK exposureresponse analyses population PK and PK/PD and other modeling and simulation activities as appropriate for the project.
- Accountable for timely execution and reporting of PKPD pharmacometrics analyses and reports for assigned projects.
- With guidance author dose justification clinical and quantitative pharmacology content for protocols CSRs global regulatory submissions including INDs CTAs IBs BLAs MAAs and pediatric plans.
- As necessary collaborate with Clinical Regulatory Biometrics Bioanalytical DMPK Toxicology and others in planning and execution of nonclinical and clinical studies.
- As required manage modeling and clinical pharmacology CROs in planning and timely execution of program deliverables.
- Ensure GxP and SOP training tasks are completed in a timely manner.
- Assist junior scientists in the design and conduct of preclinical PKPD studies to support drug candidate nomination and early preclinical drug development activities inhouse and at contract research organizations.
What We Seek
- PhD degree in pharmaceutics biochemistry pharmacokinetics pharmacology biomedical engineering or related discipline
- Minimum 5 years experience in the biotech/pharmaceutical industry in the area of preclinical drug discovery and/or development
- Experience in the conduct analysis and interpretation of in vivo preclinical pharmacokinetic and PKPD studies
- Experience with large molecule (monoclonal antibody and/or ADCs) and/or oligonucleotide therapeutic modalities
- Experience with characterization of ADME properties of drug candidates
- Industrial project team experience as either a representative or a key contributor
- Strong documentation and organizational skills
What We Will Provide To You
- The base salary range for this role is $152000 $168000. The final compensation will be commensurate with relevant experience skillset internal equity and market factors.
- Avidity offers competitive compensation and benefits including the opportunity for annual and spot bonuses stock options RSUs and a 401(k) with an employer match. In addition the comprehensive wellness program includes medical dental vision and LTD coverage and four weeks of time off.
- A commitment to learning and development including a variety of internal programming developed by and for Avidity employees opportunities for jobspecific training offered by industry and an education reimbursement program.
Avidity Biosciences
10578 Science Center Dr. Suite 125
San Diego CA
92121
O:
F:
#LIDNI
Required Experience:
Senior IC
Employment Type
Full-Time
