Senior Scientist I/II, NMR Biophysics
Senior Scientist I/II, NMR Biophysics
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1 Vacancy
Job Description
Job Description:
AbbVie is looking for a talented scientist with strong expertise in protein NMR spectroscopy to join our Lake County Illinois Biophysics team. This scientist using NMR spectroscopy and computational methods will play a central role in the discovery and advancement of small moleculebased therapeutics across a variety of disease areas. As an integral member of our team you will drive projects and collaborate across various functions within our Discovery organization. The ideal candidate should have extensive handson experience with highresolution NMR spectroscopy including design setup troubleshooting and interpretation of 1D 2D and 3D experiments along with solid understanding of spectrometer hardware. Experience with NMRbased fragment screening including protein sample optimization collection of 1D and 2D NMR screening data and use of ligandinduced chemical shift perturbations and proteinligand NOE data to dock fragments into protein binding sites would be a plus. Success in this position will require both strong collaborative skills and excellent communication skills.
Key Responsibilities:
- Design and implement NMR experiments (1D and 2D) for evaluation of ligand binding to protein targets and for fragment screening of protein targets
- Setup NMR spectrometer for the collection of proteinligand NOE data to enable ligand docking
- Process and analyze NMR screening data and structural NOE data
- Employ computational methods for CSP/NOEguided docking of ligands into protein binding sites
- Setup and troubleshoot 1D 2D and 3D experiments taken from the literature
- Prepare protein samples for NMRbased studies including buffer optimization
- Work with AbbVie personnel and vendors when necessary to maintain and repair spectrometers
- Maintain accurate and timely records of experimental results
- Interact with other members of the Biophysics Drug Discovery team to evaluate where NMR methods can be most effectively employed
- Present results at internal meetings
- Present results at external scientific meetings as appropriate
- Publish experimental results in peerreviewed journals as appropriate
- Work closely with project teams to identify and solve key questions within the domain of small molecule drug discovery
Qualifications :
Education/Experience:
Job grade level and title will be determined by the selected candidates credentials education and experience.
- PhD in Chemistry Biochemistry Biophysics or a related field
- At least 2 years of relevant academic or industry experience is required
- Extensive experience in highresolution NMR spectroscopy including design setup troubleshooting and interpretation of 1D 2D and 3D experiments
- Scripting languages and pulse sequence programing ability would be a plus
- Must be detail oriented and meticulous regarding documentation and data management
- Ability to work both independently and as part of a highly collaborative interdisciplinary team
- Effective written and verbal communication skills
- Ability to work on multiple projects in parallel and rapidly adjust to changing priorities
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our shortterm incentive programs.
This job is eligible to participate in our longterm incentive programs
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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No
Employment Type :
Fulltime
Employment Type
Full-time
