Associate Scientist
Associate Scientist
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$ 110000 - 120000
1 Vacancy
Job Description
Kyowa Kirin is a fastgrowing global specialty pharmaceutical company that applies stateoftheart biotechnologies to discover and deliver novel medicines in four disease areas: bone and mineral; intractable hematologic; hematology oncology; and rare disease. A Japanbased company our goal is to translate science into smiles by delivering therapies where no adequate treatments currently exist working from drug discovery to product development and commercialization. In North America we are headquartered in Princeton NJ with offices in California North Carolina and Mississauga Ontario.
Summary:
The Associate Scientist Pipeline Core Function will support Kyowa Kirins cell therapy pipeline programs in a highly collaborative environment. This position will play a key role in developing nextgeneration cell and gene therapy programs by providing support to pipeline projects and evaluating and implementing new technologies.
Essential Functions:
Support Cell and Gene Therapy pipeline projects by working with Project Leads to generate plasmid vectors engineered cell lines protein and antibody.
Contribute scientific and technical knowledge to project and support teams
Design initiate and optimize molecular cell based and analytical assays and methods to support Research Technical Operations and In Vivo Pharmacology teams
Collaborate and manage requests from cross functional teams to move projects from research to development
Serve as a Project Lead for technology themed projects if needed
Identify and evaluate new technologies
Maintain compliance with regulatory guidelines and internal standards
Prepare necessary documentation for project reviews (proposals monthly quarterly annual or study reports) patent applications publications and/or animal biosafety or human subject protocols.
Present research at project meetings and efficiently record experiments and data in laboratory notebooks databases and monthly reports.
Requirements:
Education
BS required MA/MS preferred in a related scientific discipline. Knowledge and background in Immunology HematologyOncology Cancer Biology or Rare Disease therapies is a plus.
Experience
8 years of handson experience and indepth knowledge of cell and gene therapy techniques and in vitro assay development. Strong background in molecular biology with practical experience in cloning molecular analytical development NGS and gene editing. Expertise in cell culture methodologies including work with cell lines primary human cells iPSCs and HSCs. Proven experience in the development and characterization of cell therapy products including HSCs iPSCs and/or CART cells. Proficient in gene editing technologies including CRISPR base editing prime editing and transposase or recombinasebased editing. Extensive experience in the molecular characterization of cell therapies with a strong preference for expertise in NGS. Familiarity with CAR design engineering screening and assay development is highly desirable Experience in developing highthroughput screening platforms for cells proteins or antibodies is preferred. Background in antibody/protein engineering protein production and purification is highly preferred. Experience in virus production transduction and analytics is a valuable plus.
Technical Skills
Strong knowledge of industry standard molecular cloning techniques including methods to scale to higher throughput. Solid understanding of cellular and molecular immunological techniques including ELISA flow cytometry in vitro functional assays reporter assays. Expertise in cell culture techniques including culture of primary cells iPSCs HSCs and cell lines from multiple species and cell manipulation techniques including transfection nucleofection and transduction. Experience with cell characterization including multicolor flow cytometry FACS MACS and single cell isolation techniques. Knowledge of gene editing techniques and analytics including CRISPR guideRNA screens knock out and knockin analysis NGS ddPCR. Experience in antibody or protein production purification and analysis including bacterial and mammalian expression systems affinity chromatography FPLC SDSPAGE/western blot HPLC Octet Carterra is a plus. Proficient in MS Office Suite.
Annualized base salary ranges from $110000 $120000 plus short term incentive bonus; actual salaries will vary and may be above or below this range commensurate with various factors including but not limited to experience education training and merit.
KKNA and all of its employees have an obligation to act in accordance with the law and with integrity in all our operations and interactions
It is the policy of Kyowa Kirin North America Inc. to provide equal employment opportunity to all qualified persons without regard to race religion creed color pregnancy sex age national origin disability genetic trait or predisposition veteran status marital status sexual orientation or affection preference or citizenship status or any other category protected by law.
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Recruitment & Staffing Agencies
Kyowa Kirin does not accept agency resumes unless contacted directly by internal Kyowa Kirin Talent Acquisition. Please do not forward resumes to Kyowa Kirin employees or any other company location; Kyowa Kirin is not responsible for any fees related to unsolicited resumes.
#LITT1 #La Jolla
Required Experience:
IC
Employment Type
Full Time
