drjobs Bioinformatics Analyst I-II - TST

Bioinformatics Analyst I-II - TST

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Job Location drjobs

Seattle - USA

Monthly Salary drjobs

$ 78894 - 118310

Vacancy

1 Vacancy

Job Description

Overview

Fred Hutchinson Cancer Center is an independent nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle Fred Hutch is the only National Cancer Institutedesignated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation HIV/AIDS prevention immunotherapy and COVID19 vaccines Fred Hutch has earned a reputation as one of the worlds leading cancer infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology infusion radiation proton therapy and related services and network affiliations with hospitals in five states. Together our fully integrated research and clinical care teams seek to discover new cures to the worlds deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration compassion determination excellence innovation integrity and respect. Our mission is directly tied to the humanity dignity and inherent value of each employee patient community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

The Bioinformatics Analyst III will provide data analysis services to researchers in the Dhodapkar lab particularly focusing on single cell genomics integration of highdimensional immunologic data and genome sequencing. This position requires the ability to work independently manage multiple overlapping demands and communicate effectively with faculty postdoctoral fellows and research staff on a wide range of topics in biology analytical biochemistry sound experimental design and data science. The Bioinformatics Analyst works closely with Shared Resources cores especially Genomics and Hutch Data core to ensure that data quality is high and that users have access to advice and continuing dialog as they review results. Given the large volumes and diverse types of data generated and integrated in Bioinformatics projects practical applied programming skills are also essential.

At Fred Hutchinson Cancer Center all employees are expected to demonstrate a commitment to our values of collaboration compassion determination excellence innovation integrity and respect.

Responsibilities

  • Analyze large sequence datasets from diverse workflows including exome capture RNAseq single cell sequencing ATACseq and CRISPR screens.
  • Work with Hutch scientists to refine computational research questions and develop analytical processes that can be applied to these genomic datasets.
  • Consult with researchers on sound experimental design.
  • Identify appropriate bioinformatics tools to meet the needs of proposed projects.
  • Partner with researchers who are developing novel assays to design appropriate processing and analysis workflows.
  • Review current literature to identify and adopt software and methodologies making new analysis capabilities available to the team.
  • Provide figures and written sections to document methods and results for manuscripts presentations and grant applications.
  • Collaborate with colleagues in the Genomics Shared Resource and the Hutch Data Core to ensure the integrity and consistency of primary data track experimental methods and metadata define standardized analysis pipelines and provide support as stakeholders analyze and interpret results.
  • Train laboratory members and collaborators on analytic workflows.
  • Upload and maintain datasets workflows and code (for example GEO Github).
  • Other duties as assigned.

Qualifications

MINIMUM QUALIFICATIONS:

Bioinformatics Analyst I:

  • Bachelors degree in bioinformatics computational biology genetics or related field.
  • Some experience in computational analysis of large complex sequencebased molecular data sets.
  • Demonstrated proficiency in R and Python 3 are essential.
  • Familiarity with workflow and scheduling software (e.g. Slurm).
  • Excellent written and verbal communication skills.

Bioinformatics Analyst II:

  • Bachelors degree in bioinformatics computational biology genetics or related field with at least three years direct experience in computational analysis of large sequencebased molecular data sets.
  • Direct experience must include bestpractice germline & somatic variant calling from exome capture data analysis of bulk RNAseq data with multiple contrasts analysis of multimodal singlecell profiling data epigenetic profiling gene set enrichment and integration of data across multiple modalities (e.g. epigenetic profiling and RNAseq).
  • Effective use of shell scripting and significant fluency in R and Python 3 are essential.
  • Facility with commonly used Bioconductor packages ggplot tidyverse etc.
  • Ability to generate and customize common data visualizations (PCA plots volcano plots Circos plots etc).
  • Familiarity with workflow and scheduling software (e.g. Slurm).
  • Excellent written and verbal communication skills are absolutely required.

PREFERRED QUALIFICATIONS:

Bioinformatics Analyst I:

  • A year of more of direct experience in computational analysis of large complex sequencebased molecular data sets.

Bioinformatics Analyst II:

  • Masters degree in bioinformatics computational biology genetics or related field.
  • Two years of experience in software development data engineering data science or related field with a track record of manipulating processing and extracting value from large datasets.
  • Experience with single cell transcriptomic analyses and associated pipelines. (e.g. Seurat).
  • Direct experience includes whole exome sequencing and integration of data across multiple modalities (e.g. TCRseq CITEseq ChIPseq ATACseq and CRISPR/Cas9 knockout screens).

Bioinformatics Analyst I: The annual base salary range for this position is from $68162 to $102211 and pay offered will be based on experience and qualifications.

Bioinformatics Analyst II:The annual base salary range for this position is from $78894 to $118310 and pay offered will be based on experience and qualifications.

Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health wellbeing and financial security. Benefits include medical/vision dental flexible spending accounts life disability retirement family life support employee assistance program onsite health clinic tuition reimbursement paid vacation (1222 days per year) paid sick leave (1225 days per year) paid holidays (13 days per year) paid parental leave (up to 4 weeks) and partially paid sabbatical leave (up to 6 months).

Additional Information


Required Experience:

IC

Employment Type

Full-Time

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