Associate Director of Pharmacometrics, Quantitative Pharmacology & Pharmacometrics (Hybrid)
Associate Director of Pharmacometrics, Quantitative Pharmacology & Pharmacometrics (Hybrid)
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$ 149400 - 235100
1 Vacancy
Job Description
Job Description
The Quantitative Pharmacology and Pharmacometrics (QP2) department drive modelinformed drug discovery and development (MIDD) to routinely enable efficient drug discovery/development and/or regulatory decisions. The Pharmacometrics group within QP2 brings an experienced leadership team deep modeling expertise and stateoftheart modeling approaches across multiple therapeutic areas and modalities to drive portfolio impact from discovery through lifecycle management. The team is externally visible and continues to be at the leading edge of building innovative state of the art tools. With MIDD as an essential component of decisionmaking at our Company this position offers an opportunity for the Associate Director to drive pipeline impact across therapy areas.
This Associate Director will work with scientists within QP2 by applying one or more of the following pharmacometrics capabilities such as population pharmacokinetics (popPK) PK/PD models exposure response (ER) models modelbased metaanalysis (MBMA) clinical trial simulations (CTS) and disease progression modeling into programs and thereby strengthening our pharmacometric capabilities on a continuous basis in decision making and driving pipeline impact. The Associate Director will perform job duties independently with minimal supervision and/or lead QP2 efforts on drug/vaccine development programs and author or coauthor strategic documents.
Associate Directors are expected to have or be developing expertise in several areas including:
Responsible for achieving results on major program drivers by implementation of one or more novel quantitative approaches that seek to improve cycle time cost/size number of trials clinical trial design and Go/No Go decisions
Framing critical drug development questions for optimizing modelinformed development
Responsible for developing and executing population pharmacokinetic models PK/PD models ER models MBMA CTS disease progression models and other pharmacometric analyses
Developing and maintaining a comprehensive understanding of global regulatory expectations for small molecules and biologics authoring regulatory documents (INDs CSRs CTDs) and representing QP2 at regulatory meetings
Required Experience:
(a Ph.D. or equivalent degree with a minimum 3 years of experience) OR (a PharmD or equivalent degree with at least 5 years of experience) OR (an MS or equivalent degree with at least 7 years of experience) where experience means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia.
Educational background in pharmacometrics biopharmaceutics pharmaceutical sciences mathematics statistics/biostatistics computational biology/chemistry chemical/biomedical engineering or a related field.
Proficiency in performing pharmacometrics analyses such as population PK PKPD ER MBMA CTS etc
Knowledge of drug development pharmacokinetics and pharmacology principles required
Preferred Experience:
Proficiency in standard pharmacometric software (e.g. R NONMEM Monolix Matlab etc.)
Strong skills in experimental design mathematical problem solving critical data analysis/interpretation and statistics
Proficiency in written and verbal communication interdisciplinary collaboration and problem scoping and planning
Good interpersonal skills that ensure teamwork and productive interactions among diverse personalities/areas of expertise
#EligibleforERP
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US and Puerto Rico Residents Only:
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U.S. Hybrid Work Model
Effective September 5 2023 employees in officebased positions in the U.S. will be working a Hybrid work consisting of three total days onsite per week Monday Thursday although the specific days may vary by site or organization with Friday designated as a remoteworking day unless business critical tasks require an onsite Hybrid work model does not apply to and daily inperson attendance is required for fieldbased positions; facilitybased manufacturingbased or researchbased positions where the work to be performed is located at a Company site; positions covered by a collectivebargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors which may include but not be limited to the primary work location and the chosen candidates relevant skills experience and education.
Expected US salary range:
$149400.00 $235100.00Available benefits include bonus eligibility long term incentive if applicable health care and other insurance benefits (for employee and family) retirement benefits paid holidays vacation and sick days. A summary of benefits is listed here.
San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance
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Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no preexisting agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.
Employee Status:
RegularRelocation:
Domestic/InternationalVISA Sponsorship:
YesTravel Requirements:
10%Flexible Work Arrangements:
HybridShift:
Not IndicatedValid Driving License:
NoHazardous Material(s):
N/ARequired Skills:
Business Intelligence (BI) Database Design Data Engineering Data Modeling Data Science Data Visualization Machine Learning Software Development Stakeholder Relationship Management Waterfall ModelPreferred Skills:
Job Posting End Date:
05/23/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Required Experience:
Director
Employment Type
Full-Time
