Principal Scientist Research Science - Genomics
Principal Scientist Research Science - Genomics
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$ 153800 - 242200
1 Vacancy
Job Description
Job Description
Translational Molecular Biomarkers (TMB) is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our companys Research laboratories. TMB laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response.
The Genomics group within TMB is seeking a highly motivated and skilled candidate for the Principal Scientist position. This role is essential for developing optimizing and deploying biomarker assays to enable clinical development at our company.
Key responsibilities will include:
- Serve as a subject matter expert in the development and validation of genomics assays collaborating with clinical and biomarker leaders as well as operations teams biostatistics companion diagnostics (CDx) and regulatory affairs.
- Interface with scientists in Discovery and Clinical development to strategically plan execute and interpret genomics results from biomarker analyses ensuring accurate conclusions are drawn .
- Execute and coordinate the development and fitforpurpose validation of assays within TMB Genomics lab labs.
- Execute and coordinate the analysis of clinical samples.
- Identify and assess emerging genomics technologies and validate those that have use within a clinical trial setting.
- Collaborate and liaise with external partners and Contract Research Organization (CROs) to manage the development validation and of genomics assays to support all therapeutic areas.
- Write memos final reports and publications summarizing data and present findings to clinical and other internal stakeholders.
Position Qualifications:
Education Minimum Requirement:
- Ph.D. MD or MD/PhD in a life sciences discipline (Biochemistry Immunology Genetics Molecular Pathology Cell Biology etc. or Chemistry
Required Experience and Skills:
- A minimum of 10 years of pharmaceutical or related experience
- A minimum of 5 years of industry experience in Genomics
- 3 years of research experience is required with an MD
- Experience leading liquid biopsy (e.g. cfDNA cfDNA ctDNA utDNA cfDNA methylation etc. biomarker research assay development and validation
- A combination of experience with various NGS platforms qPCR digital PCR and other genetic/genomic assay platforms
- Understanding of standards and guidelines for analytical method validation
- Strong record of scientific achievement (publications patents internal/external scientific/technical presentations etc.
- Strong interpersonal verbal and written communication skills
- Able to work independently represent TMB Genomics on multiple projects
- Strong leadership skills
- Ability to execute within a matrixed organization
Preferred Experience and Skills:
- Precision medicine expertise in Oncology and/or Immunology fields
- Broad knowledge of drug development process and translational medicine
- Experience with the design and development of Minimal Residual Disease (MRD) assays TCR/BCR repertoire sequencing and analysis is advantageous
- Molecular Genetic Pathology or Laboratory Medicine training
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race color age religion sex sexual orientation gender identity national origin protected veteran status disability status or other applicable legally protected a federal contractor we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws visit:
We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences perspectives skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas broad experiences backgrounds and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.
Learn more about your rights including under California Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5 2023 employees in officebased positions in the U.S. will be working a Hybrid work consisting of three total days onsite per week Monday Thursday although the specific days may vary by site or organization with Friday designated as a remoteworking day unless business critical tasks require an onsite Hybrid work model does not apply to and daily inperson attendance is required for fieldbased positions; facilitybased manufacturingbased or researchbased positions where the work to be performed is located at a Company site; positions covered by a collectivebargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors which may include but not be limited to the primary work location and the chosen candidates relevant skills experience and education.
Expected US salary range:
$153800.00 $242200.00Available benefits include bonus eligibility long term incentive if applicable health care and other insurance benefits (for employee and family) retirement benefits paid holidays vacation and sick days. A summary of benefits is listed here.
San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no preexisting agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.
Employee Status:
RegularRelocation:
Domestic/InternationalVISA Sponsorship:
YesTravel Requirements:
10Flexible Work Arrangements:
HybridShift:
Not IndicatedValid Driving License:
NoHazardous Material(s):
N/AJob Posting End Date:
04/30/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Required Experience:
Staff IC
Employment Type
Full-Time
