Senior Scientist II LC-MSMS Small Molecule and Peptide In VitroIn Vivo Bioanalysis

The Quantitative Translational and ADME Sciences (QTAS) Department at AbbVie is seeking a highly motivated and energetic bioanalytical Senior Scientist II to join the HighThroughput Automation Bioassay and Bioanalysis (HTABBA) group in North Chicago IL. The main function of this position will be supporting LCMS (Liquid ChromatographyMass Spectrometry)based bioanalysis developing methods for Small Molecules and Peptides and leading junior scientists. The ideal candidate will be experienced in development optimization and implementation of LCMS/MS bioanalytical methods to support In Vitro and preclinical In Vivo studies as well as in managing junior scientists.

Responsibilities  

• Research and develop bioanalytical LCMS/MS based methods for quantifying small molecules and peptides in biofluids and tissues.
• Perform highthroughput quantitative bioanalysis for In Vitro assays PK/PD and TK studies of small molecules and peptides in biological matrices.
• Operate and maintain LCMS/MS and automated instruments. Identify and troubleshoot instruments as needed.
• Investigate evaluate and implement new methodologies platforms and technologies to meet challenging assay requirements and throughput while maintaining effective resource utilization.
• Act as the bioanalyst leader on multiple projects interacting with collaborators and project team representatives to understand study impact define project needs and priorities and present work internally and externally.
• Manage and mentor junior scientists.
• Maintain electronic laboratory notebooks (ELN) and manage study documentation in the Laboratory Information Management System (LIMS).

Qualifications :

• PhD 4 years) M.S. 10 years) or B.S. 12 years) in analytical chemistry or related field with relevant pharmaceutical industry experience with a focus on bioanalysis and mass spectrometry.
• Strong LCMS/MS method development background with direct experience in bioanalysis/assays and understanding of both experimental design and analytical practices required.
• Expertise with current highthroughput LCMS/MS platforms (e.g. Leap autosamplers Sciex API6500/7500 triple quadrupoles) software (e.g. Sciex Analyst and/or OS Electronic notebooks LIMS Discovery Quant) and automated sample preparation (e.g. Hamilton Tecan Dispenser) platforms.
• Working experience with high resolution MS (TOF or orbitrap) and/or EchoMS for the bioanalysis of small molecules and peptides will be a plus.
• Working experience of regulated bioanalysis and/or CRO settings will be a plus.
• Excellent personal verbal and written communication skills.
• Highly organized with keen attention to detail enabling effective independent work and success within a matrix team environment.
• Desire to excel in a fastpaced environment with strong problemsolving skills and the ability to prioritize tasks and meet deadlines effectively.

Key Leadership Competencies

• Builds strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance proven ability to collaborate successfully across other groups within R&D.
• Creates a learning environment open to suggestions and experiments to drive the science in the field of interest.
• Embraces the ideas of others nurtures innovation and manages innovation to reality learns fast grasps the essence and can change course quickly when needed.
• Raises the bar and is never satisfied with the status quo.
• Highly motivated and selfdriven with the flexibility to quickly adapt to different projects.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our shortterm incentive programs. 

• This job is eligible to participate in our longterm incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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