Scientist III CMC BioProcess Purification Development

The Biologics CMC Development team at AbbVie in the Bay Area has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco the team leverages its comprehensive endtoend CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies such as bispecifics and novel modalities to human clinical studies and eventual role is within a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20 novel oncology and successfully filed two BLAs. 

This position is an onsite role in a labbased function. To be successful candidates must enjoy and thrive in an onsite highly collaborative lab environment with daily facetoface crossfunctional interactions between scientists. 

Responsibilities include: 

• Develop optimize and scaleup purification processes  

• Work with contract labs and carry out viral clearance studies 

• Support transfer processes to GMP manufacturing site for clinical material production 

• Work efficiently collaboratively and crossfunctionally toward project timelines and goals  

• Write technical reports  

• Author and deliver technical presentations 

Qualifications :

• Must have CMC protein purification development experience with standard bioprocess unit operations such as chromatography separations (resin/membrane: affinity CEX AEX HIC MM) and filtration operations (depth filtration virus filtration sterile filtration TFF) 

• Must have extensive experience with AKTA chromatographic instruments and Unicorn method writing (for systems such as AKTA Avant AKTA Purifier AKTA Pure AKTA Ready or similar) 

• Must have excellent attention to detail and ability to keep detailed written records  

• Demonstrated ability to independently design execute and interpret critical experiments to answer scientific questions 

• Demonstrated ability to learn understand and master new experimental techniques 

• Able to work collaboratively within and outside of the group 

• Able to author technical reports and presentations 

• Has a strong understanding of bioprocess engineering concepts 

• Has strong planning time management and analytical skills 

• Demonstrated scientific writing skills and strong verbal communication skills including scientific data presentations 

• Has proficiency with Microsoft Office software ability to learn new software applications

Preferred: 

• Has hands on experience with monoclonal antibody or antibodylike molecule purification at GMP pilot and/or laboratory scale  

• Has hands on experience with unit operation development including cell culture harvest affinity chromatography polishing chromatography virus filtration and ultrafiltration/diafiltration.  

• Has an understanding of analytical techniques such as HPLC LAL and ELISA 

• Has a strong understanding of statistical analysis  

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our shortterm incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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