Senior Clinical Research Associate West Coast Remote Position

This is what you will do:

The Senior Clinical Research Associate (Sr. CRA) has local responsibility for the delivery of the studies at allocated sites and is an active participant in the local country team(s). The works in close collaboration with other CRAs and the Country Operations Management (COM) Team to ensure that study commitments are achieved in a timely and efficient manner. The acts as the main contact with the study site and has the responsibility for monitoring the study conduct to ensure proper delivery and compliance of the study.

The is responsible for the selection initiation monitoring and closure of assigned sites in clinical studies in compliance with Alexion Procedural Documents international guidelines such as ICHGCP and relevant local regulations and that the sites deliver according to their respective commitment in the individual studies.

A Sr. CRA with demonstrated skillset and experience may take on additional responsibilities and tasks as needed (eg. Lead CRA etc).

You will be responsible for:

• Performing selection initiation interim monitoring and closeout visits (remote and onsite) as well as remote data checks in accordance with the timelines specified in the study specific Clinical Monitoring Plan (CMP).

• Driving performance at the sites. Proactively identifying and ensuring timely resolution to studyrelated issues and escalates them as appropriate.

• Training supporting and advising Investigators and site staff in study related matters including Risk Based Quality Management (RBQM) principles.

• Development of recruitment plans with each site and managing and supporting enrollment to ensure sites and studies meet enrollment milestones. Document recruitment barriers and mitigation plans.

• Ensure agreed monitoring KPIs are observed and remain within the agreed quality acceptable ranges (Action Items aging SDV metrics Data entry metrics query aging MV reports metrics etc.

• Preparing and finalizing monitoring visit reports in CTMS and provide timely feedback to the Principal Investigator including followup letter within required timelines and in line with Alexion SOPs.

• Ensuring timely collection/uploading of essential documents into the eTMF in accordance with ICHGCP Alexion SOPs and local requirements. Supporting/participating in regular QC checks of the eTMF

• In some countries as required CRAs are accountable for study startup and regulatory maintenance. Tasks may include collection preparation review and tracking of documents for the application process; submission of proper application/documents to EC/IRB and to Regulatory Authorities for startup and for the duration of the study.

• Contributing to the nomination and selection of potential investigators and assisting with feasibility activities

• Collaborating with local Medical Affairs and other internal stakeholders as needed.

• Following quality issue processes by escalating systematic or serious quality issues data privacy breaches or ICHGCP compliance issues to PMCO and/or Quality Group as required.

• Preparing for and collaborating with the activities associated with audits and regulatory inspections in liaison with PMCO and Quality Group.

You will need to have:

• Minimum of 4 years of CRA monitoring experience

• Bachelors degree in related discipline preferably in life science or equivalent qualification

• Excellent knowledge of international guidelines ICHGCP basic knowledge of GMP/GDP.

• Excellent knowledge of relevant local regulations.

• Good medical knowledge and ability to learn relevant Alexion Therapeutic Areas.

• Good understanding of the drug development process.

• Excellent understanding of Clinical Study Management including monitoring study drug handling and data management.

• Excellent attention to details.

• Excellent written and verbal communication skills.

• Excellent collaboration and interpersonal skills.

• Good negotiation skills.

• Demonstrates flexibility in schedule and willingness to travel (required travel may be as high as 70 during busy periods)

• Valid driving license

• Solid knowledge of clinical development processes with strong emphasis on monitoring

We would prefer for you to have:

• Ability to work in an environment of remote collaborators and in a matrix reporting structure

• Manages change with a positive approach for self team and the business. Sees change as an opportunity to improve performance and add value to the business.

• Ability to look for and champion more efficient and effective methods/processes of delivering quality clinical trials with reduced budget and in less time.

• Demonstrates ability to prioritize and manage multiple tasks with conflicting deadlines.

• Proactivity and assertivity when communicating with internal stakeholders and sites

• Ability to understand the impact of technology on projects and to use and develop computer skills while making appropriate use of systems/software in an eenabled environment.

• Team oriented and flexible; ability to respond quickly to shifting demands and opportunities.

• Experience in all study phases and in rare medical conditions preferred.

The annual base pay for this position ranges from $105735 to $158602. Hourly and salaried nonexempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors including market location jobrelated knowledge skills and experience. In addition our positions offer a shortterm incentive bonus opportunity; eligibility to participate in our equitybased longterm incentive program (salaried roles) to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an atwill position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors.

Date Posted

14Apr2025

Closing Date

Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment training compensation promotion and other terms and conditions of employment based on race color religion creed or lack thereof sex sexual orientation age ancestry national origin ethnicity citizenship status marital status pregnancy (including childbirth breastfeeding or related medical conditions) parental status (including adoption or surrogacy) military status protected veteran status disability medical condition gender identity or expression genetic information mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation please contact Alexion participates in EVerify.