Discovery Disease Area Lead - Respiratory

Job Title: Discovery Disease Area Lead Respiratory

Company Overview: At GlaxoSmithKline (GSK) we are dedicated to improving the quality of human life by leveraging scientific advancements to develop better medicines with reduced attrition. Through our Discovery Disease Area Leads (DDALs) we enable target identification selection and validation at scale driving innovation and excellence across our R&D landscape.

Job Purpose: As the Discovery Disease Area Lead Respiratory you will be at the forefront of our mission driving the discovery and validation of therapeutic targets for a range of chronic diseases such as COPD IPF and ILD. You will lead a crossfunctional highly matrixed team of scientists clinical staff and pharma experts to identify and validate highquality targets using largescale experimental and in silico approaches. Your efforts will ultimately contribute to translating human disease phenotype information into actionable therapeutic innovations.

Location: This role will be based at one of GSKs R&D hub sites in Stevenage UK or Upper Providence PA USA. The Disease Area Lead Respiratory will be expected to spend at least 23 days / week on site

Key Responsibilities:

Portfolio

• Portfolio Generation and Oversight: Generate and oversee the preCommit to Target (C2T) project portfolio in the Respiratory therapy area.
• Target Delivery: Regularly deliver pools of highpotential targets that fulfill all C2T quality criteria based on therapeutic areadefined target medicine profiles for bespoke target validation
• Senior Management Interface: Influence Senior R&D management by identifying and communicating portfolio risks and opportunities.
• Strategy : Drive development and implementation of key components of the respiratory research strategy in RTech for the Research Units.
• Team Representation: Ensure appropriate representation of lines/functions within the operational matrix team.

Respiratory biology expertise

• Respiratory Expertise: Apply deep experience in respiratory disease indications drug discovery focusing on clinically relevant target identification through humanfirst discovery approaches.
• Scientific Excellence: Drive bestinclass science across Research Technologies and Research Units (RUs).
• Strategic Partnership: Partner proactively with Research Units and Research Technology Leadership to provide strategic scientific input into disease phenotype discovery and therapeutic target identification.
• External Engagement: Maintain connection with respiratory experts KOLs and societies to ensure solid strategic guidance on emerging therapeutics understanding which could impact the portfolio and priorities.
• Clinical Insight: General understanding of clinical treatments for COPD IPF and ILD and emerging innovative trial design and biomarkers.
• Business Case Development: Lead the creation of strong business cases that align with RU and RTech strategies.
• External Opportunities Assessment: Collaborate with Business Development to assess external opportunities.

Strategic Alignment

• Framework Adherence: Ensure adherence to decision frameworks up to C2T incorporating relevant stakeholders.
• Resource Coordination: Coordinate resources from RTech and RUs to cover all steps from the patient identification strategic ideation target screening triage largescale validation and presentation.
• Risk Management: Elevate resource challenges project risks pipeline risks and opportunities to Research Tech LT.
• Resource Allocation: Make recommendations to department heads (RTech and RUs) on areas to reduce postpone or stop.

Basic Qualifications:

• Education: Minimum of an MD or PhD degree or extensive drug discovery and development experience.
• Experience: Significant progressive pharmaceutical experience required including key project leadership roles in programs that progressed to the clinic and/or approval for respiratory indications.
• Leadership Skills: Proven track record of exceptional team and crossfunctional leadership.
• R&D Expertise: Extensive with respiratory R&D programs scientific and clinical strategies.
• Research Program Design: Ability to design a comprehensive drug discovery program to reach a critical milestone

Basic Qualifications:

• Data Interpretation: Strong data interpretation and report/presentation writing skills.
• Global Mindset: Demonstrated ability to assimilate complex science quickly and work globally.
• Crossfunctional Collaboration: Ability to work crossfunctionally crossgeography and with highlevel managers and executives.
• Communication Skills: Excellent executive communication skills.
• Time Management: Ability to manage multiple demands and priorities on time lead teams gain alignment and drive decisionmaking.
• Networking: Access to internal and external networks of experts.

Why GSK

Uniting science technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose to unite science technology and talent to get ahead of disease together so we can positively impact the health of billions of people and deliver stronger more sustainable shareholder returns as an organisation where people can thrive. We prevent and treat disease with vaccines specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies investing in four core therapeutic areas (infectious diseases HIV respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders its also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired encouraged and challenged to be the best they can be. A place where they can be themselves feeling welcome valued and included. Where they can keep growing and look after their wellbeing. So if you share our ambition join us at this exciting moment in our journey to get Ahead Together.

As an Equal Opportunity Employer we are open to all talent. In the US we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity race/ethnicity colour national origin religion gender pregnancy marital status sexual orientation gender identity/expression age disability genetic information military service covered/protected veteran status or any other federal state or local protected class**US only).

We believe in an agile working culture for all our roles. If flexibility is important to you we encourage you to explore with our hiring team what the opportunities are.

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