Research Fellow - Department of Cancer and Genomic SciencesGrade 7
Research Fellow - Department of Cancer and Genomic SciencesGrade 7
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
£ 36130 - 45413
1 Vacancy
Job Description
Position Details
Department of Cancer and Genomic Sciences School of Medical Sciences College of Medicine and Health
Location: University of Birmingham Edgbaston Birmingham UK
Full time starting salary is normally in the range 36130 to 45413 with potential progression once in post to 48149
Grade 7
Full Time Fixed Term contract up to March 2028
Closing date: 01 May 2025
Background
The postholder will join a multidisciplinary team investigating structure/function relationships in the cellular activity of a hydroxylaseligase pathway involved in gene expression control and nucleic acid exciting new pathway is unprecedented in biology and holds huge potential for discovery and scientific research career development. It builds on our discovery of a cytoplasmic lysyl hydroxylase that modifies a translation factor GTPase (Nature Chem Bio 2018; Genet Med 2023; Structure 2024; Cell Mol Life Sci 2021. Here in this highly competitive BBSRCfunded project you will unravel for the first time the role of this hydroxylated GTPase in nuclear ubiquitin biology. The findings will have significant importance for our understanding of fundamental cellular processes in both healthy and diseased cells. This project is hosted in the laboratory of Professor Mat Coleman Head of Department of Cancer and Genomic Sciences School of Medical Sciences University of Birmingham UK (a world Top 100 University that ranks 59th for Life Sciences and Medicine).
- Work as part of a BBSRCfunded collaborative team investigating protein hydroxylase biology and its role in regulating novel nuclear ubiquitin biology.
- Apply cell biology biochemistry and omics approaches to identify and analyse novel enzyme/substrate complexes and new ubiquitylation targets involved in transcriptional elongation and nucleic acid repair.
- Analyse and interpret research findings and results and contribute to manuscripts and grant applications. Present findings at national and international conferences and explore opportunities for career development.
Main Duties
The responsibilities may include some but not all of the responsibilities outlined below.
- Develop research objectives and proposals for own or joint research with assistance of a mentor if required
- Contribute to writing bids for future research funding
- Collect analyse and interpret experimental data and integrate results with ongoing cell biological work.
- Apply knowledge in a way which develops new intellectual understanding
- Disseminate research findings for publication research seminars etc
- Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline
- Contribute to developing new models techniques and methods
- Undertake management/administration arising from research
- Contribute to Departmental/School researchrelated activities and researchrelated administration
- Contribute to enterprise business development and/or public engagement activities of manifest benefit to the College and the University often under supervision of a project leader
- Collect research data; this may be through a variety of research methods such as scientific experimentation literature reviews and research interviews
- Present research outputs including drafting academic publications or parts thereof for example at seminars and as posters
- Provide guidance as required to support staff and any students who may be assisting with the research
- Deal with problems that may affect the achievement of research objectives and deadlines
- Promotes equality and values diversity acting as a role model and fostering an inclusive working culture.
Person Specification or Required Knowledge Skills Qualifications Experience
- First degree in Biochemistry or a related discipline a PhD (or one close to completion) or equivalent qualification and postdoctoral experience in nucleic acid repair ubiquitin biology and/or transcription.
- Demonstrable experience in DNA/RNA damage analyses RNA biology and/or analyses of gene expression control including through advanced omics techniques.
- Demonstrable experience in deriving and analysing novel cell models including through the application of Crispr RNA interference and/or targeted protein degradation.
- Demonstrable experience in ubiquitin ligase cell biology and biochemistry.
- Experience of proteomics and genomics.
- High level analytical capability and familiarity with appropriate data collection/processing/analysis approaches and software.
- Ability to communicate complex information clearly.
- Evidence of contribution to grant applications and papers.
- Evidence of teaching experience and supervision of undergraduate Masters and PhD students
- Fluency in relevant models techniques or methods and ability to contribute to developing new ones
- Ability to assess resource requirements and use resources effectively
- Contribute to the planning and organising of the research programme and/or specific research project
- Coordinate own work with others to avoid conflict or duplication of effort
- Knowledge of the protected characteristics of the Equality Act 2010 and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly.
Further particulars can be foundhere
Informal enquiries to Mathew Coleman email:
We believe there is no such thing as a typical member of University of Birmingham staff and that diversity in its many forms is a strength that underpins the exchange of ideas innovation and debate at the heart of University life. We are committed to proactively addressing the barriers experienced by some groups in our community and are proud to hold Athena SWAN Race Equality Charter and Disability Confident accreditations. We have an Equality Diversity and Inclusion Centre that focuses on continuously improving the University as a fair and inclusive place to work where everyone has the opportunity to succeed. We are also committed to sustainability which is a key part of our strategy. You can find out more about our work to create a fairer university for everyoneon our website.
Employment Type
Full-Time
