Process Systems Engineer

At Lilly we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis Indiana. Our employees around the world work to discover and bring lifechanging medicines to those who need them improve the understanding and management of disease and give back to our communities through philanthropy and volunteerism. We give our best effort to our work and we put people first. Were looking for people who are determined to make life better for people around the world.

Engineer / Research Scientist (R5

Senior Engineer / Senior Research Scientist (R6

Synthetic Molecule Design and Development

Process Design and Development: Process Systems Engineer

At Lilly we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis Indiana. Our 39000 employees around the world work to discover and bring lifechanging medicines to those who need them improve the understanding and management of disease and give back to our communities through philanthropy and volunteerism. We give our best effort to our work and we put people first. Were looking for people who are determined to make life better for people around the world.

Organizational Overview

Lillys Synthetic Molecule Design and Development (SMDD) is involved in key activities for the development of active pharmaceutical ingredients from preclinical phases through commercialization of drug substances and drug products for small molecules synthetic oligonucleotides and peptides. Our scientists develop key technical and business solutions across the portfolio using their deep technical expertise to speed up testing of the clinical hypothesis and overall drug development. SMDD tackles this diversity of responsibilities by recognizing that an even greater diversity of talents and cultures is necessary to deliver the next generation of life changing medicines to patients.

Position Overview

SMDD is seeking outstanding process system engineering candidates to work within the process design and development team. The position presents an opportunity to develop and apply computerized modelbased solutions to accelerate the development of new medicines. It also presents the opportunity to work side by side with chemists analytical chemists formulation scientists and engineers to develop new technical solutions to accelerate our portfolio. The position will be based in Indianapolis where research is conducted in a new state of the art development facility.

Candidates must demonstrate a history of strong technical depth scientific leadership and a willingness to promote a collaborative teambased approach to problem solving. The responsibilities and opportunities for this role include:

• Apply process systems engineering fundamentals towards designing and optimizing pharmaceutical manufacturing processes (drug product and drug substance processes) including but not limited to solids operations chemical reactions and separation processes using modeling simulation and optimization tools in conjunction with data analysis.
• Design appropriate strategies to apply a variety of computational tools to support the development and scaleup of pharmaceutical manufacturing processes.
• Implement and execute the necessary data analysis models and/or simulations to support to the design or scaleup of pharmaceutical manufacturing processes.
• Analyze and interpret data collected from laboratory experiments and/or from manufacturing (including parameter estimation).
• Actively participate in the design of process conditions for process understanding (experiments) or for material production in manufacturing (nominal conditions).
• Understand and utilize thermodynamics and material characterization techniques as an informing factor to modelbased solutions.
• Develop userfriendly computational tools to be deployed across SMDD to support the development of specific manufacturing platforms.
• Train the SMDD general community in the use of platform computational tools.
• Serve as a member of integrated commercial teams responsible for the development and demonstration of new processes.
• Take leadership in the supervision of the compliance with regulations guidelines procedures and practice governing drug research and development including the departmental and corporate standard operating good manufacturing practices and safety procedures.
• Collaborate closely with multifunctional organizations such as Product Delivery Project Management Quality Manufacturing and Regulatory to execute and deliver material and information for clinical trials and regulatory submissions.
• Develop the external manufacturing network oversee activities and install key capabilities within contract manufacturing organizations (CMOs).
• Engage in a highly collaborative work environment across and beyond SMDD and Lilly including external academic researchers and precompetitive collaborations.
• Direct and mentor less experienced scientists and engineers to deliver the portfolio and innovation projects.
• Promote diverse thought and experience to deliver innovative solutions that address unmet technical needs.
• Publish and present original research externally author internal technical documents and develop and document control strategies for new product registration applications (manufacturing process and development history portions).

Additional Skills and Preferences:

• Experience across multiple disciplines of process systems engineering (modeling optimization control statistics numerical methods programming).
• Knowledge and experience building fundamental empirical or hybrid models as appropriate.
• Awareness of simulation tools across scales (DEMCFD FEM PBM etc)
• Experience in parameter estimation and handling of data uncertainty.
• Experience with modeling and simulation and data analytics software packages (e.g Python MATLAB gPROMS Aspen GAMS Pyomo R).
• Knowledge and familiarity with data generating sources and automation architectures.
• Strong foundations in numerical methods optimization thermodynamics and transport phenomena.
• Excellent oral communication and documentation skills.
• Demonstrate ability to effectively collaborate with multidisciplinary teams.
• Demonstrate leadership behaviors with ability to accept challenges seek opportunities to remove barriers influence without authority and lead in areas of uncertainty
• Demonstrate exemplary teamwork/interpersonal skills
• Demonstrate problem solving attention to detail and result oriented behaviors in a fastpaced environment.

Education Requirements:

• PhD in Chemical Engineering or related discipline.

Additional Information

• Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of race gender protected veteran status disability or any other legally protected status.
• Travel: 0 to 10
• Position Local: Indianapolis IN.

Eli Lilly and Company Lilly USA LLC and our wholly owned subsidiaries (collectively Lilly) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly please email Lilly Human Resources for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age race color religion gender sexual orientation gender identity gender expression national origin protected veteran status disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa Middle East Central Asia Network African American Network Chinese Culture Network Early Career Professionals Japanese International Leadership Network (JILN) Lilly India Network Organization of Latinos at Lilly PRIDE (LGBTQ Allies) Veterans Leadership Network Womens Network Working and Living with Disabilities. Learn more about all of our groups.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly please complete the accommodation request form for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age race color religion gender identity sex gender expression sexual orientation genetic information ancestry national origin protected veteran status disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa Middle East Central Asia Network Black Employees at Lilly Chinese Culture Network Japanese International Leadership Network (JILN) Lilly India Network Organization of Latinx at Lilly (OLA) PRIDE (LGBTQ Allies) Veterans Leadership Network (VLN) Womens Initiative for Leading at Lilly (WILL) enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidates education experience skills and geographic location. The anticipated wage for this position is